[Mucociliary transport in larynx affected with cancer].

Otolaryngol Pol

Kliniki Otolaryngologii Katedry Chorób Uszu, Nosa, Gardła i Krtani Akademii Medycznej im. K. Marcinkowskiego, Poznaniu.

Published: July 1993

Mucociliary transport in the subglottic space of 60 human larynges excised for ca was investigated using a marking substance--Sudan B. The reflex method was used for observations of ciliary activity. The video film and photographs were taken during observations. Mucociliary transport was demonstrable in subglottic space of 55% of investigated larynges. The direction of the transport was pathological, but invariable during observations. 37% of the larynges without transport showed ciliary activity. The presence and absence of the mucociliary transport was independent activity. The presence and absence of the mucociliary transport was independent of the location and the degree of the clinical progression. Analysis of the factors influencing on disturbances of mucociliary transport was carried out.

Download full-text PDF

Source

Publication Analysis

Top Keywords

mucociliary transport
20
subglottic space
8
ciliary activity
8
activity presence
8
presence absence
8
absence mucociliary
8
transport independent
8
transport
7
mucociliary
5
[mucociliary transport
4

Similar Publications

Objective: Cystic fibrosis (CF) is a clinical entity defined by aberrant chloride (Cl) ion transport causing downstream effects on mucociliary clearance (MCC) in sinonasal epithelia. Inducible deficiencies in transepithelial Cl transport via CF transmembrane conductance regulator (CFTR) has been theorized to be a driving process in recalcitrant chronic rhinosinusitis (CRS) in patients without CF. We have previously identified that brief exposures to bacterial lipopolysaccharide (LPS) in mammalian cells induces an acquired dysfunction of CFTR in vitro and in vivo.

View Article and Find Full Text PDF

Recently, there has been growing interest in knowing the best hygrometry level during high-flow nasal oxygen and non-invasive ventilation (NIV) and its potential influence on the outcome. Various studies have shown that breathing cold and dry air results in excessive water loss by nasal mucosa, reduced mucociliary clearance, increased airway resistance, reduced epithelial cell function, increased inflammation, sloughing of tracheal epithelium, and submucosal inflammation. With the Coronavirus Disease 2019 pandemic, using high-flow nasal oxygen with a heated humidifier has become an emerging form of non-invasive support among clinicians.

View Article and Find Full Text PDF

Introduction: Incidences of infections with Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) are still high and treatment guidelines lack specific recommendations for outpatients with Coronavirus-induced disease 2019 (COVID-19). Phytomedicine ELOM-080, an enhancer of mucociliary clearance (MCC), showed benefits as add-on therapy in hospitalised COVID-19 patients.

Methods: This randomised, double-blind, placebo-controlled proof-of-concept study investigated whether outpatients with mild to moderate acute symptomatic COVID-19 would benefit from a 14-day treatment with ELOM-080 with regard to potential early treatment effects on cough and further typical COVID-19 symptoms.

View Article and Find Full Text PDF

Primary ciliary dyskinesia (PCD, OMIM 244400) is a rare genetic disorder that affects motile cilia and is characterised by impaired mucociliary clearance of the airway epithelium, which results in chronic upper and lower airway infections. While short-read next-generation sequencing technology has been used for the genetic testing of PCD, its effectiveness is limited in identifying variants in the gene because of the nearly identical pseudogene As we confirmed that the gene was not expressed in airway cells, we obtained nasal mucosa biopsy specimens for total RNA sequencing (RNA-seq) with library enrichment using exome oligos. Among the 34 nasal samples from patients suspected of having PCD, three aberrant splicing patterns in were identified in two samples.

View Article and Find Full Text PDF

The (re)emergence of aerosol delivery: Treatment of pulmonary diseases and its clinical challenges.

J Control Release

January 2025

Univ Brest, Inserm, EFS, UMR 1078, GGB, F-29200, Brest, France; CHU de Brest, Service de Génétique Médicale et de Biologie de la Reproduction, F-29200 Brest, France. Electronic address:

Aerosol delivery represents a rapid and non-invasive way to directly reach the lungs while escaping the hepatic first-pass effect. The development of pulmonary drugs for respiratory diseases such as cystic fibrosis, lung infections, pulmonary fibrosis or lung cancer requires an enhanced understanding of the relationships between the natural physiology of the respiratory system and the pathophysiology of these conditions. This knowledge is crucial to better predict and thereby control drug deposition.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!