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Athlete Selective Androgen Receptor Modulators Abuse: A Systematic Review.
Am J Sports Med
January 2025
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Background: Selective androgen receptor modulators (SARMs) are small-molecule compounds that exert agonist and antagonist effects on androgen receptors in a tissue-specific fashion. Because of their performance-enhancing implications, SARMs are increasingly abused by athletes. To date, SARMs have no Food and Drug Administration approved use, and recent case reports associate the use of SARMs with deleterious effects such as drug-induced liver injury, myocarditis, and tendon rupture.
View Article and Find Full Text PDFIdentification of channel shifting patterns and bank erosion-prone sites and challenges of riverine livelihood in the lower Tista River basin.
Environ Sci Pollut Res Int
January 2025
Department of Geography, Rampurhat College, PO-Rampurhat, Dist-Birbhum, 731224, India.
In fluvial environments, the shifting of river channels and bank erosion are frequently caused by both natural and anthropogenic factors. Riverine hazards like bank erosion and course alterations offer severe issues to the riparian villages along the lower basin of the Tista River in India, which substantially influence the livelihoods of inhabitants living there. This research addressed river channel shifting tendency and identified major bank erosion-prone villages along the lower course of the Tista River and challenges to the livelihoods of the riparian people.
View Article and Find Full Text PDFUterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities.
Reprod Biol Endocrinol
January 2025
Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Huddinge, Stockholm, 14183, Sweden.
Background: A didelphic uterus represents a unique and infrequent congenital condition in which a woman possesses two distinct uteri, each with its own cervix. This anomaly arises due to partial or incomplete merging of the Müllerian ducts during the developmental stages in the womb. Accounting for uterine malformations, a didelphic uterus is a relatively rare condition, affecting approximately 0.
View Article and Find Full Text PDFLet's "game" it!: Dangerous games, a new health challenge.
Leg Med (Tokyo)
December 2024
Institut de Médecine Légale, IML/UMJ, CHU Poitiers, rue de la Milétrie, CS 90577, 86021 POITIERS Cedex, France; Faculté de Médecine et de Pharmacie, Univ Poitiers, 6 rue de la Milétrie, 86073 Poitiers, France; Unité de Recherche Clinique, Centre Hospitalier Henri-Laborit, 370 av Jacques Cœur, 86000 Poitiers, France. Electronic address:
In the past several years, children and adolescents have increasingly been enticed into playing dangerous and challenging games, particularly through social networks. Epidemiological data regarding this phenomenon are particularly difficult to come by, as is information regarding the somatic and psychological consequences of these activities, which can end up having fatal outcomes. We here report the case of a suspicion of child abuse that turned out to be due to participation in a challenge game known as "The Deodorant Challenge" by a 10-year-old child who presented with burn-like lesions.
View Article and Find Full Text PDFInvestigation of circulating miR-182-3p, miR -382-3p and miR -93, miR -142-3p involved in tamoxifen resistance and sensitivity in luminal-subtype breast cancer patients: a case-control study.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Breast cancer (BC) commonly expresses estrogen receptors (ERs); hence, endocrine therapy targeting ERs is considered an effective treatment. Tamoxifen (TAM) resistance is an essential clinical complication leading to cancer progression and metastasis. This study investigated MicroRNAs (miRNAs) potentially implicated in drug resistance (miR-182-3p, miR-382-3p) or sensitivity (miR-93, miR- 142- 3p).
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