AI Article Synopsis
- The study examined the link between neuronal death and calcium balance in Alzheimer’s disease (AD) brains by analyzing changes in calbindin-immunoreactive neurons.
- Neuronal counts from autopsies revealed that these neurons were significantly lost in AD patients compared to controls, particularly in cortical layer II.
- The research also indicated that the decline of calbindin-immunoreactive neurons is worsened by aging in AD brains, suggesting a potential connection between calcium homeostasis and the development of AD.
Article Abstract
To investigate the relationship between neuronal death and intracellular calcium homeostasis in brains from patients with Alzheimer's disease (AD), we quantitatively analyzed morphological changes of calbindin-immunoreactive neurons. Neuronal counts were made in the autopsy brains from 6 control and 6 AD patients. Calbindin-immunoreactive neurons were mainly distributed in cortical layer II and were selectively lost in the AD brains. Further, the number of calbindin-immunoreactive neurons showed a negative correlation with age in the control group. These findings strongly suggest that age-related reduction of calbindin-immunoreactive neurons may be exaggerated in AD brains and change in calcium homeostasis may be involved in the pathogenesis of AD.
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| http://dx.doi.org/10.1016/0304-3940(93)90388-2 | DOI Listing |
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