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Dorsal root ganglion proteins in Friedreich's ataxia. | LitMetric

Dorsal root ganglion proteins in Friedreich's ataxia.

Neurosci Lett

Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.

Published: December 1993

The polypeptide composition of dorsal root ganglia from 8 human controls, 6 Friedreich's ataxia (FA) patients and 1 patient with diabetic neuropathy was studied by sodium dodecyl sulphate (SDS)-polyacrylamide gel electrophoresis (PAGE). Silver-stained gels demonstrated a decrease in a 40-kDa protein in FA patients. This protein appeared to be present in normal amounts in the diabetic ganglion, suggesting that this 40-kDa protein deficiency was not simply a reflection of reduced neuronal numbers but may be specific for FA.

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http://dx.doi.org/10.1016/0304-3940(93)90377-wDOI Listing

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