Until now, only a few strains of V. cincinnatiensis have been isolated. This study describes a further three isolates which originated in one case from a stool specimen of an immunocompromised elder patient suffering from enteritis and in two cases from the rennin stomachs of aborted bovine fetuses. These strains grew on TCBS, CIN, MacConkey and XLD plates. Their biochemical activities were dependent on NaCl concentration, in particular the formation of indole, lysine and ornithine decarboxylases, arginine dihydrolase, the reduction of nitrate and behaviour in the Voges-Proskauer test. Moreover, lysine decarboxylase and nitrate reductase were temperature-dependent. The knowledge of these hitherto unknown phenotypical characteristics may facilitate the diagnosis of the pathogen.
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http://dx.doi.org/10.1016/s0934-8840(11)80417-2 | DOI Listing |
BMC Plant Biol
January 2025
Department of Field Crops, Faculty of Agriculture, Necmettin Erbakan University, Konya, 42310, Türkiye.
Background: Innovation in crop establishment is crucial for wheat productivity in drought-prone climates. Seedling establishment, the first stage of crop productivity, relies heavily on root and coleoptile system architecture for effective soil water and nutrient acquisition, particularly in regions practicing deep planting. Root phenotyping methods that quickly determine coleoptile lengths are vital for breeding studies.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, United States.
There are few in vitro models available to study microglial physiology in a homeostatic context. Recent approaches include the human induced pluripotent stem cell model, but these can be challenging for large-scale assays and may lead to batch variability. To advance our understanding of microglial biology while enabling scalability for high-throughput assays, we developed an inducible immortalized murine microglial cell line using a tetracycline expression system.
View Article and Find Full Text PDFPediatr Nephrol
January 2025
Pediatric Nephrology Services, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605006, India.
Background: Limited research exists regarding the genetic profile, clinical characteristics, and outcomes of refractory rickets in children from India.
Methods: Patients with refractory rickets aged ≤ 18 years were enrolled. Data regarding clinical features, etiology, genotype-phenotype correlation, and estimated glomerular filtration rate (eGFR) were recorded.
Clin Trials
January 2025
Rare Diseases Team, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Background/aims: Rare disease drug development faces unique challenges, such as genotypic and phenotypic heterogeneity within small patient populations and a lack of established outcome measures for conditions without previously successful drug development programs. These challenges complicate the process of selecting the appropriate trial endpoints and conducting clinical trials in rare diseases. In this descriptive study, we examined novel drug approvals for non-oncologic rare diseases by the U.
View Article and Find Full Text PDFPlants (Basel)
January 2025
School of Life Sciences, Fudan University, Shanghai 200433, China.
: The functional traits of twigs and leaves are closely related to the ability of plants to cope with heterogeneous environments. The analysis of the characteristics of twigs and leaves and leaf thermal dissipation in riparian plants is of great significance for exploring the light energy allocation and ecological adaptation strategies of plant leaves in heterogeneous habitats. However, there are few studies on the correlation between the twig-leaf characteristics of riparian plants and their heat dissipation in light heterogeneous environments.
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