An LC method for measuring complex formation equilibria by competitive chelation.

J Pharm Biomed Anal

Pharmaceutical Sciences, Sterling Winthrop Pharmaceutical Research Division, Collegeville, PA 19426-0900.

Published: October 1993

A method, entailing the use of a competitor ligand, is described for measuring complex formation constants by HPLC. The log of the formation constant of Gd(III) 2,6-bis(aminomethyl)pyridinetetraacetate was determined to be 18.6, a previously unreported value.

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http://dx.doi.org/10.1016/0731-7085(93)80059-aDOI Listing

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