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Background: Seasonal malaria chemoprevention (SMC) is an effective malaria preventive intervention in sub-Sahara Africa. However, as with any other drug-based intervention, the large-scale deployment of this strategy could lead to Amodiaquine plus Sulfadoxine-Pyrimethamine (AQSP) drug pressure on the circulating parasites population with selection for specific alleles that could compromise the impact of the intervention in the near future. This study aimed to assess the distribution of the Pfmdr1 mutation involved in resistance to AQ before and after the annual campaign of SMC in the health district of Nanoro.
View Article and Find Full Text PDFAnaemia at 36 weeks of pregnancy: Prevalence and determinants among antenatal women attending peri-urban facilities in a developing country, Ghana.
PLOS Glob Public Health
September 2024
Department of Nutritional Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Northern Region, Ghana.
Anaemia as a critical health condition greatly upsurges the risk of pregnancy complications leading to preventable maternal mortalities and long-term morbidities. Therefore, identifying anaemia-associated factors is vital for planning relevant interventions in resource-constrained regions in Sahelian Africa. This study aimed to assess the prevalence and determinants of anaemia at 36 weeks of pregnancy among antenatal women in a peri-urban municipality of Ghana.
View Article and Find Full Text PDFPrevalence of mutations associated with artemisinin partial resistance and sulfadoxine-pyrimethamine resistance in 13 regions in Tanzania in 2021: a cross-sectional survey.
Lancet Microbe
October 2024
National Institute for Medical Research, Dar es Salaam, Tanzania; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Biochemistry, Kampala International University in Tanzania, Dar es Salaam, Tanzania. Electronic address:
Article Synopsis
- The study investigates the prevalence of the Arg561His mutation in the Plasmodium falciparum k13 gene and other antimalarial resistance markers in Tanzania, particularly near the border with Rwanda, due to rising concerns about resistance in the region.* -
- A total of 6855 blood samples from malaria-positive individuals were collected and genotyped, revealing an overall mutation prevalence of 7.7% in the Kagera region, with higher rates closer to Rwanda.* -
- Genetic analysis indicates a possible connection between some local P. falciparum strains and those previously recorded in Rwanda, suggesting a regional spread of resistance.*
Long-Term Low-Dose Pyrimethamine Use for the Prevention of Ocular Toxoplasmosis Recurrences: A Cohort Study.
Ocul Immunol Inflamm
November 2024
Department of Ophthalmology and Visual Science, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Purpose: To describe the effect of long-term, low-dose pyrimethamine for the prevention of ocular toxoplasmosis (OT) recurrences.
Methods: Sixty-three consecutive patients with inactive ocular toxoplasmosis and positive toxoplasma IgG serology were included. Pyrimethamine (25 mg) + folinic acid (15 mg) were administered every other day (three times weekly) for 12 months.
Diagnosis of Congenital Toxoplasmosis: Challenges and Management Outcomes.
Cureus
January 2024
Neonatology Department, Centro Materno-Infantil do Norte, Centro Hospitalar Universitário de Santo António, Porto, PRT.
Introduction Congenital toxoplasmosis (CT), despite being mostly subclinical at birth, can cause disabling disease in the fetus and lead to long-term sequelae. It is an important cause of chorioretinitis in infants and adolescents. Data on postnatal treatment are controversial, and there is a lack of universal guidelines.
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