The cause of atypical odontalgia has been related to many factors, including psychological ones. Animal experiments indicate that tooth pulp extirpation provokes a deafferentation, which may or may not induce pain, depending on unknown factors. The research described here showed that human tooth avulsion induces atypical odontalgia when it is carried out in migraine and cluster headache sufferers. Conversely, no sensation is reported by personally and familiarly headache-exempt subjects who underwent the same type of tooth extraction.
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