Direct evidence for the synaptic resonance phenomenon.

Via the parameter optimization method, well documented in the literature, data on the facilitated release of acetylcholine from the preganglionic nerve terminals during short trains of impulses have been quantitatively generalized within the framework of the previously developed theory of the double barrier synapse. This allowed unique transformation of the set of discrete measurements of facilitated transmitter release into continuous dependencies of facilitation on time and frequency and, subsequently, into the resonant curves having very readily interpreted computational meaning. Thus direct evidence is produced that an overall effect of facilitory action of presynaptic stimulation does indeed reflect resonant properties of the terminal in a form of the previously predicted synaptic resonance phenomenon.