Perilymphatic fistulas of the round or oval window in a traumatic context or following middle ear surgery or pathology, are reported. Rapid surgical exploration secures the best clinical results.
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Differential growth and flowering capacity of tulip bulbs and the potential involvement of PHOSPHATIDYLETHANOLAMINE-BINDING PROTEINS (PEBPs).
Biol Direct
March 2025
Laboratory of Molecular Biology, Cluster Plant Developmental Biology, Wageningen University and Research, 6708 PB, Wageningen, The Netherlands.
Background: Tulipa gesneriana reproduces vegetatively by the development of bulb clusters from axillary meristems in the scales of a mother bulb. While part of the daughter bulbs in a cluster develop into large, flowering bulbs, others stay small and vegetative under the same environmental conditions. This study aims to investigate how these different developmental fates are orchestrated.
View Article and Find Full Text PDFThe asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision.
Elife
March 2025
Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China.
The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for the first time, thus representing the beginning of developmental patterning. Here, we demonstrate that the molecular chaperone heat shock protein A2 (HSPA2), a member of the 70 kDa heat shock protein (HSP70) family, is asymmetrically expressed in the late 2-cell stage of mouse embryos. The knockdown of in one of the 2-cell blastomeres prevented its progeny predominantly towards the inner cell mass (ICM) fate.
View Article and Find Full Text PDFSingle-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells.
Elife
March 2025
Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, United States.
Accurate specification of female and male germ cells during embryonic development is critical for sexual reproduction. Primordial germ cells (PGCs) are the bipotential precursors of mature gametes that commit to an oogenic or spermatogenic fate in response to sex-determining cues from the fetal gonad. The critical processes required for PGCs to integrate and respond to signals from the somatic environment in gonads are not well understood.
View Article and Find Full Text PDFLongitudinal single cell profiling of epitope specific memory CD4+ T cell responses to recombinant zoster vaccine.
Nat Commun
March 2025
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
Vaccination leads to rapid expansion of antigen-specific T cells within in the first few days. However, understanding of transcriptomic changes and fates of antigen-specific T cells upon vaccination remains limited. Here, we investigate the fate of memory CD4+ T cells upon reactivation to recombinant zoster vaccine for shingles at cellular and transcriptional levels.
View Article and Find Full Text PDFAn atlas of RNA-dependent proteins in cell division reveals the riboregulation of mitotic protein-protein interactions.
Nat Commun
March 2025
Research Group "RNA-Protein Complexes & Cell Proliferation", German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ribonucleoprotein complexes are dynamic assemblies of RNA with RNA-binding proteins, which modulate the fate of RNA. Inversely, RNA riboregulates the interactions and functions of the associated proteins. Dysregulation of ribonucleoprotein functions is linked to diseases such as cancer and neurological disorders.
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