The effects of prolonged androgen treatment (testosterone propionate, 10 mg/day for 56 days) on fear reactions in ewes were studied using a battery of tests previously designed and validated. These tests involved situations classically reported to induce fear in sheep: isolation from conspecifics, surprise, and presence of a human. Testosterone-treated ewes differed from controls in a number of behavioral characteristics which indicate that they are less fearful in the various test situations. Their overall scores were respectively 9.5 vs 11.5 (P < 0.05) in the isolation test, 7.9 vs 13.1 (P < 0.001) in the surprise test, and 7.8 vs 13.2 (P < 0.001) in the human test. Testosterone treatment thus clearly reduces fear reactions in ewes subjected to nonsocial situations that are typically fear-eliciting.
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http://dx.doi.org/10.1006/hbeh.1993.1032 | DOI Listing |
J Am Chem Soc
January 2025
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.
Host-guest supramolecular fluorescence probes have garnered significant attention in the detection and sensing of bioactive molecules due to their functionalization potential, adjustable physical properties, and high specificity. However, such probes that reliably, rapidly, and specifically measure neurotransmitter dynamics at the cellular and in vivo level have yet to be reported. Herein, we present a supramolecular fluorescent chemosensor designed for norepinephrine (NE) detection, showing an exceptional response and specificity through host-guest complexation.
View Article and Find Full Text PDFNeuropharmacology
January 2025
School of Psychological Sciences, The University of Haifa, Haifa, Israel; The Integrated Brain and Behavior Research Center (IBBRC), University of Haifa, Haifa, Israel. Electronic address:
Fear is a fundamental emotion that triggers rapid and automatic behavioral response. Fear is known to suppress reward-seeking behaviors, interrupt previous activities to prioritize defensive responses and lead to rapid switch to defensive reactions. Dopamine (DA) plays a complicated role in the choice and performance of actions and it has a potential interaction of innate actions with the presence of fear.
View Article and Find Full Text PDFPorto Biomed J
January 2025
Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.
Background: Fear and horror induce autonomic protective responses, acting as "survival intelligence." Pupillometry is an innovative method that captures real-time autonomic nervous system reactions to stress.
Objective: To evaluate the feasibility of pupillometry to assess the acute response to a passive real-life stressor-viewing a truthful war scene.
BMC Health Serv Res
January 2025
Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur , Tamil Nadu, 603203, India.
Introduction: Several adverse drug reactions (ADRs) go unreported within a healthcare setting despite the risks they cause. We therefore decided to conduct this study in order to recognize the obstacles that hinder the healthcare professionals (HCPs) in a tertiary care hospital in Kattankulathur, Tamil Nadu from reporting ADRs and what strategies ought to be implemented.
Methods: We carried out a cross-sectional study among the HCPs such as doctors, pharmacists and nurses within our institution.
Perioper Med (Lond)
January 2025
Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: The unfamiliar atmosphere of the operating room, waiting for anesthesia, and the process of surgery and anesthesia are some of the factors causing fear and anxiety in patients. It leads to physical and psychological pressure on patients. Better understanding of patients' feelings, beliefs, or fears and recording their experiences for optimal care after surgery is helpful.
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