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Qualitative and Quantitative Luminescence Detection of 2,6-Dipicolinic Acid and Levofloxacin Based on a High-Nuclearity Eu(III) Nanomolecular Sensor.

Anal Chem

December 2024

Zhejiang Key Laboratory of Carbon Materials, Key Lab of Biohealth Materials and Chemistry of Wenzhou, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.

Rapid and accurate testing of 2,6-dipicolinic acid (DPA) and levofloxacin (LFX) has been attracting much attention due to the fact that the former is an important biomarker of anthrax spores and the latter is a third-generation fluoroquinolone drug and has been recognized as an important environmental pollutant. Herein, we report the preparation of a 13-metal Eu(III) nanomolecular sensor (molecular sizes: 2.0 × 2.

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Soil Sample Analysis of Contaminated Animal Burial Sites.

Microorganisms

September 2024

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.

Article Synopsis
  • Environmental contamination with anthrax spores in pastoral regions poses significant risks to livestock and the local economy, highlighting the need for ongoing monitoring.
  • The study reviewed 232 soil samples from contaminated sites in Kars province, Türkiye, over 14 years, revealing that viable spores were detected in 58.6% of samples, with certain positions showing higher concentrations.
  • The findings indicate that anthrax spores can persist in the soil for over a decade, suggesting that standard burial methods may not effectively decontaminate affected areas, emphasizing the necessity for thorough bacteriological monitoring and appropriate decontamination strategies.
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The wars in Iraq and Afghanistan required that forensic science was used beyond the traditional law enforcement and criminal justice goals and applied to military operations. The 9/11 terror attacks in the United States (US) inspired further attacks in the Western World and highlighted the importance of national and international intelligence sharing for counterterrorism operations. Following the 9/11 attacks, anthrax was disseminated in the US mail system, demonstrating a successful modern use of biological agents.

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Aluminum salt-based adjuvants like alum, alhydrogel and Adju-Phos are by far the most favored clinically approved vaccine adjuvants. They have demonstrated excellent safety profile and currently used in vaccines against diphtheria, tetanus, pertussis, hepatitis B, anthrax etc. These vaccinations cause minimal side effects like local inflammation at the injection site.

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