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Inhibition of Chitinase-3-like Protein 1 Reduced Epithelial-Mesenchymal Transition and Vascular Epithelial Cadherin Expression in Oesophageal Squamous Cell Carcinoma.
Iran J Biotechnol
July 2024
Department of Pathology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Background: Oesophageal cancer (EC) is one of the common malignant tumors, and the prognosis of patients is poor. Further exploration of EC pathogenesis remains warranted.
Objective: The relationship between vascular epithelial cadherin (VE-cadherin) and chitinase-3-like protein 1 (CHI3L1) in EC is currently unknown.
Oncogene 5'-3' exoribonuclease 2 enhances epidermal growth factor receptor signaling pathway to promote epithelial-mesenchymal transition and metastasis in non-small-cell lung cancer.
Cytojournal
November 2024
Department of Respiratory and Critical Care Medicine, Wuyi County First People's Hospital, Jinhua, Zhejiang, China.
Objective: Epithelial-mesenchymal transition (EMT) and metastasis are the primary causes of mortality in non-small-cell lung cancer (NSCLC). 5'-3' exoribonuclease 2 (XRN2) plays an important role in the process of tumor EMT. Thus, this investigation mainly aimed to clarify the precise molecular pathways through which XRN2 contributes to EMT and metastasis in NSCLC.
View Article and Find Full Text PDFLaser-capture microdissection for spatial transcriptomics of immunohistochemically detected neurons.
J Biol Chem
December 2024
Laboratory of Reproductive Neurobiology, HUN-REN Institute of Experimental Medicine, Budapest, 1083 Hungary. Electronic address:
We developed a versatile 'IHC/LCM-Seq' method for spatial transcriptomics of immunohistochemically detected neurons collected with laser-capture microdissection (LCM). IHC/LCM-Seq uses aluminon and polyvinyl sulfonic acid for inventive RNA-preserving strategies to maintain RNA integrity in free-floating sections of 4% formaldehyde-fixed brains. To validate IHC/LCM-Seq, we first immunostained and harvested striatal cholinergic interneurons with LCM.
View Article and Find Full Text PDFImmunohistochemical Detection of CD147 Expression in Adenocarcinoma of the Prostate: A Case-Control Study.
Prostate Cancer
December 2024
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, Al-Neelain University, Khartoum, Sudan.
Prostate cancer is the most common noncutaneous malignancy among men worldwide, including in Sudan, where it represents a significant public health challenge. CD147, a transmembrane glycoprotein implicated in tumor progression, invasion, and metastasis, has shown potential as a prognostic biomarker in various cancers. This retrospective case-control study aimed to evaluate CD147 expression in prostate adenocarcinoma among Sudanese men and its association with tumor grade.
View Article and Find Full Text PDFComparison of E-Cadherin Expression in Oral Verrucous Carcinoma and Normal Oral Mucosa: An Immunohistochemical Study.
Cureus
November 2024
Department of Oral Pathology and Microbiology, Manav Rachna Dental College, Faridabad, IND.
Introduction Oral verrucous carcinoma (OVC), a low-grade variation of oral squamous cell carcinoma (OSCC), is distinguished by endophytic development and a pebbly, mammillated surface. OVC, often referred to as Ackerman's tumor, has been known to involve lymph nodes but rarely spreads to regional and distant locations; when the primary tumor grows, it frequently involves surrounding tissues. Histopathologically, it has a thicker basement membrane, many reduplications, and a large area of inflammatory infiltration that resembles OSCC.
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