Congenital nasal stenosis is a new disease concept which was reported, for the first time, by Knegt-Junk et al in 1988. The authors experienced 10 cases of this disease from 1986 to 1990. Radiography revealed that transverse width of the bony nasal passage of these patients was smaller than that of normal infants. Infants with nasal stenosis showed respiratory distress after birth and half of them had a low body weight and/or other congenital defects. Our patients were treated by nasal or oral intubation or by installation of nasal vasoconstrictor into the nasal passage. Four cases showed improvement up to 4 months of age, 6 others after 6 months of age. Tracheostomy was performed in one case. We must differentiate this disease from incomplete choanal atresia or nasal aperture stenosis. Our cases were similar to that of Knegt-Junk et al. We speculate that the congenital origin of this disease stems from a disturbance in embryologic development of the middle third of the face. Accordingly, we measured the diameter of the nasal passage radiography and recognized a narrow transverse width in the bony portion of the nose.
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Comput Biol Med
January 2025
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:
In this study, we examined the correlation between anatomical dimensions, spray administration parameters, pressure drop across 40 pediatric nasal cavities, and in vitro posterior drug delivery (PDD) using Nasacort ALLERGY 24HR and FLONASE SENSIMIST nasal suspensions sprays, with different nozzle and actuation designs. The importance of each parameter and their interaction in the outcome (PDD) was evaluated. To do so, initially we measured anatomical and administration-related parameters, and the pressure drop of each cavity.
View Article and Find Full Text PDFSurg Radiol Anat
January 2025
Faculty of Dental Medicine, University of Porto, Porto, Portugal.
Purpose: The greater palatine foramen (GPF) represents the inferior opening of the greater palatine canal and is located posterolaterally on both sides of the hard palate. The aim of this study is to morphometrically characterise the GPF and to determine its anatomical relationships in a Portuguese population.
Methods: A retrospective study was performed based on the clinical records which included all permanent teeth erupted and a cone beam computed tomography (CBCT) of the entire maxilla.
Microbiome
January 2025
Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Background: Numerous studies have confirmed a close relationship between the pathogenicity of influenza and respiratory microbiota, but the mechanistic basis for this is poorly defined. Also, the majority of these studies have been conducted on murine models, and it remains unclear how far these findings can be extrapolated from murine models to other animals. Considering that influenza A virus is increasingly recognized as an important canine respiratory pathogen, this study investigated the cross-talk between nasal and lung tissues mediated by microbes and its association with influenza susceptibility in a beagle dog model.
View Article and Find Full Text PDFActa Biomater
January 2025
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510275, China. Electronic address:
Following cerebral ischemia, reperfusion injury can worsen ischemia-induced functional, metabolic disturbances, and pathological damage upon blood flow restoration, potentially leading to irreversible harm. Yet, there's a dearth of advanced, localized drug delivery systems ensuring active pharmaceutical ingredient (API) efficacy in cerebral protection during ischemia-reperfusion. This study introduces a multivalent bioadhesive nanoparticle-cluster, merging bioadhesive nanoparticles (BNPs) with dendritic polyamidoamine (PAMAM), enhancing nose-to-brain delivery and brain protection efficacy against cerebral ischemia-reperfusion injuries (CIRI).
View Article and Find Full Text PDFLaryngoscope
January 2025
Department of Otolaryngology, Head and Neck Surgery, The University of Tokyo, Tokyo, Japan.
Objective: The goal of this study was to better understand the epidemiology, clinical characteristics, and treatment outcomes of head and neck sarcomas using real-world data from Japan.
Methods: Using the Japanese Head and Neck Cancer Registry, we identified 438 patients who were pathologically diagnosed with head and neck sarcoma between 2011 and 2020. We compared epidemiological, clinical, and prognostic data for the different histological types of sarcoma.
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