AI Article Synopsis
- The cytochrome c gene (cycA) from Aspergillus nidulans has been sequenced and is a single copy in its haploid genome, coding for a polypeptide with 112 amino acids.
- The cycA gene shares 87% identity with the Neurospora crassa cytochrome c gene and about 72% with the Saccharomyces cerevisiae CYC1 gene, with the latter used to help isolate cycA in A. nidulans.
- The sequence contains two introns, one of which is conserved, and expression of the cycA gene increases significantly in the presence of oxygen and during heat-shock, but is not inhibited by glucose.
Article Abstract
The cytochrome c gene (cycA) of the filamentous fungus Aspergillus nidulans has been isolated and sequenced. The gene is present in a single copy per haploid genome and encodes a polypeptide of 112 amino acid residues. The nucleotide sequence of the A. nidulans cycA gene shows 87% identity to the DNA sequence of the Neurospora crassa cytochrome c gene, and approximately 72% identity to the sequence of the Saccharomyces cerevisiae iso-1-cytochrome c gene (CYC1). The S. cerevisiae CYC1 gene was used as a heterologous probe to isolate the homologous gene in A. nidulans. The A. nidulans cytochrome c sequence contains two small introns. One of these is highly conserved in terms of position, but the other has not been reported in any of the cytochrome c genes so far sequenced. Expression of the cycA gene is not affected by glucose repression, but has been shown to be induced approximately tenfold in the presence of oxygen and three- to fourfold under heat-shock conditions.
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| http://dx.doi.org/10.1007/BF00277343 | DOI Listing |
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