The chiasma map of D. melanogaster is inferred from the genetic map, giving correspondences between physical and genetic locations. Crossing-over is reduced near the centromere and telomeres. If chiasmata occur preferentially near the telomere they must be distal to genetic loci. A precept of Bridges and Morgan is discussed, which Drosophila genetics neglected but chromosome mapping in other organisms should follow.
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http://dx.doi.org/10.1038/hdy.1976.105 | DOI Listing |
Front Oncol
February 2023
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Purpose: Deep-learning effectively predicts dose distributions in knowledge-based radiotherapy planning. Using anatomical information that includes a structure map and computed tomography (CT) data as input has been proven to work well. The minimum distance from each voxel in normal structures to planning target volume (DPTV) closely affects each voxel's dose.
View Article and Find Full Text PDFCells
August 2022
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
Pituitary adenomas (PAs) are the second most common primary brain tumor and may develop from any of the cell lineages responsible for producing the different pituitary hormones. DNA methylation is one of the essential epigenetic mechanisms in cancers, including PAs. In this study, we measured the expression profile and promoter methylation status of carbohydrate sulfotransferase 7 (CHST7) in patients with PA; then, we investigated the effect of the CHST7 methylation status on the proliferation and differentiation of PAs.
View Article and Find Full Text PDFGenetics
August 2022
CNRS, IRL 3614 Evolutionary Biology and Ecology of Algae, 29688 Roscoff, France.
Cytological data from flowering plants suggest that the evolution of recombination rates is affected by the mating system of organisms, as higher chiasma frequencies are often observed in self-fertilizing species compared with their outcrossing relatives. Understanding the evolutionary cause of this effect is of particular interest, as it may shed light on the selective forces favoring recombination in natural populations. While previous models showed that inbreeding may have important effects on selection for recombination, existing analytical treatments are restricted to the case of loosely linked loci and weak selfing rates, and ignore the stochastic effect of genetic interference (Hill-Robertson effect), known to be an important component of selection for recombination in randomly mating populations.
View Article and Find Full Text PDFEye Brain
March 2022
Department of Ophthalmology, Robert Debré Hospital, Reims, France.
Purpose: To evaluate the relationship between different macular thickness parameters analyzed by SD-OCT and the central visual field (VF) evaluated with automated kinetic perimetry in a cohort of patients with pituitary tumors.
Methods: Data from patients with pituitary adenoma treated at Reims University Hospital between October 1st, 2017, and May 31st, 2018 were collected. All patients underwent an automated kinetic perimetry and a SD-OCT to map the ganglion cell complex (GCC), the ganglion cell layer (GCL) thickness and the retinal nerve fiber layer (RNFL) using devices from two different manufacturers.
Handb Clin Neurol
July 2021
Departments of Ophthalmology and Neurology, University of Iowa, Iowa City, IA, United States. Electronic address:
Perimetry is the quantitation of the visual field. This is done with a perimeter and usually involves measuring visual thresholds to a range of light stimuli. It is used clinically to map patterns of visual loss due to damage to the sensory visual system.
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