Breaking of myocardial pumping function was shown in experiments in anesthesized dogs under hyperthermia. The end-systolic, end-diastolic and stroke volume was decreased under those conditions. The effectiveness of Frank-Starling mechanism was reduced in severe hyperthermia.
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Sci Rep
January 2025
Biorobotics Laboratory, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
Despite their potential, exoskeletons have not reached widespread adoption in daily life, partly due to the challenge of seamlessly adapting assistance across various tasks and environments. Task-specific designs, reliance on complex sensing and extensive data-driven training often limit the practicality of the existing control strategies. To address this challenge, we introduce an adaptive control strategy for hip exoskeletons, emphasizing minimal sensing and ease of implementation.
View Article and Find Full Text PDFJ Neurophysiol
January 2025
Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile.
The cardiorespiratory and metabolic response to exercise has been associated with meeting the organism's metabolic demands during physical exertion. Of note, an incremental exercise is characterized by ) cardiodynamic phase related to cardiac output enhancement mainly determined by a positive chronotropic response, ) ventilatory threshold one, associated with a significant contribution of cardiovascular and pulmonary ventilation, and ) ventilatory threshold two, correlated with a tremendous increase in breathing and metabolic responses to exercise. Notably, it has been shown that the ventilatory response to exercise increases concomitantly with the release and accumulation of metabolites (i.
View Article and Find Full Text PDFCan J Physiol Pharmacol
November 2024
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
This study aimed to examine the effect of thiopental monotherapy as well as its combination with different agents used in anesthesia induction, on cardiac function and redox state of rats with type 1 diabetes mellitus (T1DM). A total of 40 male rats were used in this study and randomly divided into five groups: thiopental (TIO), fentanyl + thiopental (FEN + TIO), remifentanil + thiopental (REM + TIO), midazolam + thiopental (MID + TIO), and dexmedetomidine + thiopental (DEX + TIO). Animals were anesthetized by intraperitoneal injection of thiopental 85 mg/kg, fentanyl 0.
View Article and Find Full Text PDFNeuroimage
October 2024
Institute for Drug and Alcohol Studies, Department of Psychiatry, Virginia Commonwealth University, 203 East Cary Street, Suite 202, Richmond 23219, VA, United States; Department of Psychiatry, Virginia Commonwealth University, VA, United States; Department of Pharmacology and Toxicology, Virginia Commonwealth University, VA, United States; Department of Neurology, Virginia Commonwealth University, VA, United States; C. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, VA, United States.
The central autonomic network (CAN) serves as a regulatory hub with top-down regulatory control and integration of bottom-up physiological feedback via the autonomic nervous system. Heart rate variability (HRV)-the time variance of the heart's beat-to-beat intervals-is an index of the CAN's affective and behavioral regulatory capacity. Although neural functional connectivities that are associated with HRV and CAN have been well studied, no published report to date has studied effective (directional) connectivities (EC) that are associated with HRV and CAN.
View Article and Find Full Text PDFArch Oral Biol
January 2025
Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia; Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia; Department of Human Pathology, I.M. Sechenov First Moscow State Medical University, 8 Trubetskaya St., 119991 Moscow, Russian Federation.
Objective: To evaluate the possible effects of apical periodontitis (AP) on cardiac function, structure, and oxidative stress (OS) in rats with diabetes mellitus type 2 (T2DM).
Design: Forty-eight (Wistar albino, male) rats were randomized into four groups: control healthy (CTRL), normoglycemic with AP (AP), T2DM, and T2DM with AP (T2DM+AP). T2DM was induced by streptozotocin and a high-fat diet.
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