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Impairment of the T cell memory response in chronic lymphocytic leukemia patients after SARS-CoV-2 vaccination.
Vaccine
January 2025
Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, Università del Piemonte Orientale, Novara, Italy; Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, 28100 Novara, Italy. Electronic address:
Article Synopsis
- CLL patients are particularly vulnerable to COVID-19 due to weakened immune systems from their condition and treatments, highlighting the critical need for vaccination.
- The study assessed T cell responses to COVID-19 vaccines using an AIM assay, revealing that 28.60% of CLL patients did not respond to vaccination, and 61.90% exhibited impaired CD8+ T cell responses.
- The AIM test could serve as an effective tool for identifying non-responders and evaluating the immune protection of CLL patients following vaccination.
Guided by the integrated behavioral model, the authors interviewed 14 Black breast cancer survivors ( = 14) who had participated in a breast cancer clinical trial. This study aimed to better understand what may motivate Black women to engage in medical research and decide to participate in medical research. Findings revealed that Black women's altruistic desires to serve others and their communities are greatly influenced by the need to leave a "legacy" of better treatment for other Black women.
View Article and Find Full Text PDFModern humans don't always leave cultural or technological evidence. Yet, Mbuti artifacts, like net-hunting tools and patterns, reveal their modern cognitive capacity. They create geometric and musical structures requiring specific working memory seen in modern .
View Article and Find Full Text PDFCompact multiplex PCR device for HIV-1 and HIV-2 viral load determination from finger-prick whole blood in resource-limited settings.
Biosens Bioelectron
March 2025
Department of Electrical Engineering, Pennsylvania State University, University Park, 16802, USA; Department of Biomedical Engineering, Pennsylvania State University, University Park, 16802, USA. Electronic address:
The human immunodeficiency virus (HIV) remains a major global health concern for which accurate viral load monitoring is essential for the management of HIV infection. The advent of antiretroviral therapy (ART) has transformed once-fatal HIV disease into a manageable chronic condition that now makes the need for VL testing which aims to satisfy international suppression targets 95-95-95 al l the more essential. Therefore, considering the complexity and diversity of HIV infection, it is essential to develop rapid diagnostic technologies suitable for different clinical situations.
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