Considering the fact that one of the indicators of effects of hypoxia in pilots could be an altered speech we have analysed changes in uttering a sound (A) in our examinees, pilot-students, aged 21-23, under effects of hypoxia only, the associated effects of hypoxia and mental loading and under conditions of normal barometric pressure. In the frequency and three dimensional representation of the selected sound, there have been analysed frequency components, intensity, duration and quality of the sound. It has been found that acute hypoxia causes deep structural and durational changes. During the stay at the simulated altitude the contributing factor to these changes which should be taken into account is the mental loading--performance of the test. It has been obvious that the same degree of hypoxia associated with mental activities during test performance causes deeper degradation of the voice structure both in the resistant subjects, and especially in individuals sensitive to the lack of oxygen compared to that under effects of hypoxia only and that under physiologic conditions.
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Chem Biomed Imaging
January 2025
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Due to uncontrolled cell proliferation and disrupted vascularization, many cancer cells in solid tumors have limited oxygen supply. The hypoxic microenvironments of tumors lead to metabolic reprogramming of cancer cells, contributing to therapy resistance and metastasis. To identify better targets for the effective removal of hypoxia-adaptive cancer cells, it is crucial to understand how cancer cells alter their metabolism in hypoxic conditions.
View Article and Find Full Text PDFBMJ Oncol
February 2024
Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Cancer remains one of the most formidable challenges in modern medicine, due to its complex and dynamic nature, which demands innovative therapeutic approaches. One major challenge to cancer treatment is the tumour microenvironment and in particular tumour hypoxia (low oxygen levels), which contributes to tumour progression and immune evasion. At the cellular level, this is primarily governed by hypoxia-inducible factor (HIF).
View Article and Find Full Text PDFPan Afr Med J
January 2025
Cardiovascular Department, The Affiliated People´s Hospital of Ningbo University, Ningbo, 315000, ZheJia, China.
This case presents a patient who experienced hypoxia and hypotension following the infusion of industrial-grade anhydrous ethanol into the vein of Marshall (VOM) during atrial fibrillation radiofrequency ablation. The hypotension lasted for at least three days, requiring dopamine support, while hypoxia persisted for over a week. The prolonged nature of these symptoms posed a diagnostic challenge.
View Article and Find Full Text PDFMetabol Open
March 2025
First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Anemia is a frequent, yet increasingly recognized, comorbidity in diabetes mellitus (DM), with prevalence often driven by multifactorial mechanisms. Hematinic deficiencies, common in this population, may arise from associated comorbidities or medications, such as metformin, as well as other drugs commonly employed for DM-related conditions. Among contributing factors, diabetic kidney disease (DKD) plays a pivotal role, with anemia developing more frequently and being more pronounced in earlier stages, than in CKD of other causes.
View Article and Find Full Text PDFRSC Adv
January 2025
State Key Laboratory for New Textile Materials & Advanced Processing Technology, Wuhan Textile University Wuhan 430200 P. R. China
Thermodynamic therapy (TDT) is a promising alternative to photodynamic therapy (PDT) by absorbing heat through thermosensitive agents (TSAs) to generate oxygen-irrelevant highly toxic free radicals. Therefore, TDT can be a perfect partner for photothermal therapy (PTT) to achieve efficient synergistic treatment of anoxic tumors using a single laser, greatly simplifying the treatment process and overcoming hypoxia limitations. However, the issues of how to improve the stability and delivery efficiency of TSAs still need to be addressed urgently.
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