Approximately 30 years ago, the finding that prostate acid phosphatase (PAP) was antigenically distinct from other acid phosphatases opened an era in the measurement of prostate cancer. Many immunoassays have been developed but their clinical significance has been limited. Studies comparing one or more assays in the same population of men with prostate cancer population have concluded that no differences were found in the sensitivities of the assays when the upper limits of normal were selected to provide equal specificities.
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