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Photoinduced Online Enrichment-Deglycosylation of Glycolipids for Enhancing Lipid Coverage and Identification in Single-Cell Mass Spectrometry.
Anal Chem
November 2024
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, P. R. China.
Article Synopsis
- * A new method using photoinduced enrichment-deglycosylation has been developed to improve the detection of GSLs within a mass spectrometry system by selectively removing sugar groups and enhancing their visibility.
- * This innovative technique significantly increased GSL detection coverage (by 9-fold) and identified more lipid types in single neurons, revealing that certain GSLs changed notably after nerve injury.
Specific iron binding to natural sphingomyelin membrane induced by non-specific co-solutes.
J Colloid Interface Sci
February 2025
Ames National Laboratory, and Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, United States. Electronic address:
Hypothesis: Sphingomyelin (SPM), a crucial phospholipid in the myelin sheath, plays a vital role in insulating nerve fibers. We hypothesize that iron ions selectively bind to the phosphatidylcholine (PC) template within the SPM membrane under near-physiological conditions, resulting in disruptions to membrane organization. These interactions could potentially contribute to the degradation of the myelin sheath, thereby playing a role in the development of neurodegenerative diseases.
View Article and Find Full Text PDFModulating a model membrane of sphingomyelin by a tricyclic antidepressant drug.
Chem Phys Lipids
September 2024
Department of Physics, School of Natural Sciences, Shiv Nadar Institution of Eminence, NH 91, Tehsil Dadri, Uttar Pradesh 201214, India. Electronic address:
Tricyclic medicine such as amitriptyline (AMT) hydrochloride, initially developed to treat depression, is also used to treat neuropathic pain, anxiety disorder, and migraines. The mechanism of functioning of this type of drugs is ambiguous. Understanding the mechanism is important for designing new drug molecules with higher pharmacological efficiency.
View Article and Find Full Text PDFAnalysis of Globotriaosylceramide (Gb) in Liquid Urine: A Straightforward Assay Using Tandem Mass Spectrometry.
Curr Protoc
June 2024
Division of Medical Genetics, Department of Laboratory Medicine, CIUSSS de l'Estrie-CHUS, Sherbrooke, Quebec, Canada.
Article Synopsis
- Fabry disease (FD) is caused by mutations in the GLA gene, leading to the buildup of a fatty substance called globotriaosylceramide (Gb), which can cause serious health issues like heart problems, kidney failure, and strokes.
- A new methodology involves analyzing urine samples for Gb and creatinine using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) to provide accurate results for diagnosing and monitoring FD.
- The protocol has been fully validated, showing high stability for sample conditions and providing age-specific Gb/creatinine reference limits for effective patient evaluation.
Cell-Penetrating Drug Carrier by Molecular Recognition of Sphingomyelin on Plasma Membranes.
Langmuir
May 2024
Center for Supramolecular Chemical Biology, State Key Laboratory of Supramolecular Structure and Materials, School of Life Sciences, Jilin University, Changchun 130012, China.
Plasma membranes not only maintain the intracellular microenvironment through their phospholipid bilayer but also eliminate exogenous compounds outside the cell membranes. Most drugs especially with high polarity are prevented from entering into cells to exert their effects. Therefore, it is of great significance to design effective drug carriers with a penetrating ability toward plasma membranes.
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