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Circle-seq reveals that eccDNA may be a key blood biomarker for HBV-associated liver cancer.
Front Genet
January 2025
Hepatology Department, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China.
Introduction: Extrachromosomal circular DNA (eccDNA) regulates tumor occurrence and development. Relevant eccDNA profiles have been established for various types of cancer; however, the eccDNA expression profiles in the blood of patients with hepatocellular carcinoma (HCC) and liver cirrhosis (LC) remain unknown. The present study aimed to investigate the eccDNA expression profiles in the blood of patients with HCC and LC.
View Article and Find Full Text PDFArtificial Intelligence in Pediatric Epilepsy Detection: Balancing Effectiveness With Ethical Considerations for Welfare.
Health Sci Rep
January 2025
Department of Research The Medical Research Circle (MedReC) Goma Democratic Republic of the Congo.
Background And Aim: Epilepsy is a major neurological challenge, especially for pediatric populations. It profoundly impacts both developmental progress and quality of life in affected children. With the advent of artificial intelligence (AI), there's a growing interest in leveraging its capabilities to improve the diagnosis and management of pediatric epilepsy.
View Article and Find Full Text PDFUnlabelled: Myosin-IC (myo1c) is a class-I myosin that supports transport and remodeling of the plasma membrane and membrane-bound vesicles. Like other members of the myosin family, its biochemical kinetics are altered in response to changes in mechanical loads that resist the power stroke. However, myo1c is unique in that the primary force-sensitive kinetic transition is the isomerization that follows ATP binding, not ADP release as in other slow myosins.
View Article and Find Full Text PDFAction toward sound sources enhances auditory spatial confidence: on the metacognitive consequences of reaching to sounds.
Psychol Res
January 2025
Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, TN, Italy.
Each perceptual process is accompanied with an evaluation regarding the reliability of what we are perceiving. The close connection between confidence in perceptual judgments and planning of actions has been documented in studies investigating visual perception. Here, we extend this investigation to auditory perception by focusing on spatial hearing, in which the interpretation of auditory cues can often present uncertainties.
View Article and Find Full Text PDFMetabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review.
Clin Oral Investig
January 2025
Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, M5G 1G6, Canada.
Objectives: Apical periodontitis (AP) is an inflammatory immune response in periapical tissues caused by microbial infections. Failure of root canal treatment or delayed healing is often due to intracanal or extra-radicular bacteria. However, beyond microbial factors, the patient's systemic health can significantly influence the progression and healing of AP.
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