Following stimulation of one ear with white noise (WN) or 0.5, 1 and 2 kHz tone bursts a statistically valid mean reduction in the amplitude of delayed evoked otoacoustic emissions (DEOE), elicited from the contralateral ear by bursts of the same frequencies, was observed in 10 people (19-23-years-old) with normal hearing. This reduction only appeared in response to a contralateral stimulus delivered 7, 8 and 9 ms earlier than that used to produce the DEOE. This inhibitory effect was just referable to the activity of the medial olivocochlear efferent system (MOES). This research has shown that: (i) the cochlear interdependence is linked to activation of the MOES; (ii) in man the activity of MOES is inhibitory and only appears for a stimulus of the same frequency or (for WN) including that used to elicit DEOE; (iii) the cochlear interdependence is frequency selective and the MOES thus establishes a direct functional interdependence between homologous sectors of the organs of Corti on the two sides; (iv) DEOE would appear to be no more than partly generated by outer hair cells (OHC) of the organ of Corti in relation to the frequency of the stimulus employed, thus substantiating the hypothesis that in their production the effects of an 'active' mechanism, represented by the 'slow' contractile activity of the OHC, is overlain by those of a 'passive' mechanism formed by the oscillations induced by the movements of the stapes in the basilar membrane (BM) or in the set of membranes and liquids of cochlear canal.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1017/s0022215100124703 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The cochlea phenotypically differs from the vestibule in the Gfi1 mouse.
Dev Dyn
January 2025
Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, China.
Background: Previous studies with Gfi1-mutated lines have shown that Gfi1 is essential for hair cell maturation and survival.
Results: We analyzed the phenotype of another Gfi1-mutated line Gfi1 in the inner ears of neonates at P5-7 and found that the cochlea phenotypically differed from the vestibule in the Gfi1 mouse. Specifically, there was a marked reduction in hair cells in the cochlea, which was characterized by greater reductions in the outer hair cells but far less reductions (mainly in the basal turn) in the inner hair cells, whereas the vestibular hair cells remained unaffected.
The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss.
Int J Mol Sci
May 2024
Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Article Synopsis
- Age-related hearing loss, or presbycusis, is a complex condition affecting many older adults and involving various mechanisms, particularly metabolic dysfunction in the stria vascularis essential for hearing.
- Research has shifted focus back to the stria vascularis, highlighting its role in age-related hearing loss and examining factors like ion transport changes, pigmentation shifts, and inflammation.
- This review emphasizes the need for a comprehensive understanding of metabolic and sensorineural mechanisms in age-related hearing loss to inform future research and potential treatment strategies.
characterization of novel hyaluronan-antioxidant conjugates as potential topical therapeutics against hearing loss.
Front Pharmacol
February 2024
Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, United States.
Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment options often require invasive medical procedures, and to date, there are no FDA-approved drug therapies. While the causes can be diverse, noise induced hearing loss is unequivocally associated with oxidative stress and inflammation, and subsequent damage to the inner ear structures.
View Article and Find Full Text PDFOn the interdependence of insertion forces, insertion speed, and lubrication: Aspects to consider when testing cochlear implant electrodes.
PLoS One
January 2024
Department of Otolaryngology, Hannover Medical School, Hannover, Germany.
Objectives: During the insertion of cochlear implant (CI) electrode arrays, forces occur which may cause trauma and poorer hearing outcomes. Unfortunately, research groups investigating factors influencing insertion forces come to contradicting results, especially regarding insertion speed. This study was conducted to investigate the origin of these contradicting results and to determine how different testing conditions influence experimental findings.
View Article and Find Full Text PDFQuality Standard for Rehabilitation of Young Deaf Children Receiving Cochlear Implants.
Medicina (Kaunas)
July 2023
Department of Medical Specialties, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
More and more children with severe-to-profound hearing loss are receiving cochlear implants (CIs) at an early age to improve their hearing and listening abilities, speech recognition, speech intelligibility, and other aspects of spoken language development. Despite this, the rehabilitation outcomes can be very heterogeneous in this population, not only because of issues related to surgery and fitting or the specific characteristics of the child with his/her additional disabilities but also because of huge differences in the quality of the support and rehabilitation offered by the therapist and the family. These quality standards for the rehabilitation of young deaf children receiving CIs are developed within the European KA202 Erasmus+ project "VOICE"-vocational education and training for speech and language therapists and parents for the rehabilitation of children with CIs, Ref.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!