Relationship between antifungal activity and hydrophobicity of kojic acid derivatives.

Folia Microbiol (Praha)

Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Polytechnic University, Bratislava.

Published: January 1994

Twenty three kojic acid derivatives were tested in the agar diffusion test against twenty five dermatophytic fungi. The inhibitory effects at equal doses (10 mg/L) were correlated with the 1-octanol-water partition coefficients of the compounds. An improvement in antifungal activity can be achieved by increasing the hydrophobicity of the compounds.

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http://dx.doi.org/10.1007/BF02898762DOI Listing

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