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Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection.
NIHR Open Res
January 2025
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, England, L69 7BE, UK.
Background: PROTECT ( Platform Randomised evaluation of clinical Outcomes using novel TEChnologies to optimise antimicrobial Therapy) has brought together a team of researchers to design a platform trial to rapidly evaluate and adopt into care multiple diagnostic technologies, bringing immediate benefit to patients. Rapid diagnostic tests will be used to identify patients at risk of deterioration from severe infection, before they become critically unwell. The platform will assess their comparative clinical effectiveness and cost-effectiveness relative to current standard of care.
View Article and Find Full Text PDFHigh-risk clones harboring β-lactamases: 2024 update.
Heliyon
January 2025
Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Carbapenem-resistant is defined by the World Health Organization as a "high priority" in developing new antimicrobials. Indeed, the emergence and spread of multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacteria increase the morbidity and mortality risk of infected patients. Genomic variants of that display phenotypes of MDR/XDR have been defined as high-risk global clones.
View Article and Find Full Text PDFEditorial: Postural control priorities and effective motor learning.
Front Hum Neurosci
January 2025
Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Pandemic preparedness in Vietnam: a review of health system resilience and areas for improvement.
J Glob Health
January 2025
SingHealth Duke-NUS Global Health Institute, National University of Singapore, Singapore.
In this viewpoint, we explore Vietnam's health system vulnerabilities and its national response to the COVID-19 pandemic, as well as critical areas of health system resilience, including health financing, workforce distribution, information systems, and governance. While Vietnam achieved early success through strong governance and mass vaccination campaigns, the pandemic revealed weaknesses in resource procurement, workforce imbalance, and limitations of its health information system. There are challenges in ensuring the rapid disbursement of financial resources and reliance on imported medical supplies, which delayed response times.
View Article and Find Full Text PDFVancomycin-resistant Enterococcus prevalence and its association along the food chain: a systematic review and meta-analysis.
J Antimicrob Chemother
January 2025
Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Background: Vancomycin-resistant Enterococcus (VRE) are present across the One Health continuum and pose a considerable risk for transmission along the food chain. This systematic review and meta-analysis estimates the prevalence of VRE colonization in livestock, food of animal origin, and in human populations.
Methods: Embase, MEDLINE and CAB Abstracts were searched for eligible literature.
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