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An experimental study on the synergic damage of chemical solutions and stress to coal.
Sci Rep
January 2025
CSIRO Mineral Resources, Brisbane, QLD, 4069, Australia.
This paper investigates the impact of treatment with chemical solutions of varying pH values on the micro-macroscopic damage in coal samples under load, employing a combination of Small Angle X-ray Scattering (SAXS) experiments and uniaxial compression tests. The experimental results show that soaking coal samples in NaOH, HCl, and distilled water for 7 days leads to reductions in uniaxial compressive strength by 39.19%, 47.
View Article and Find Full Text PDFCardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications.
Int J Psychiatry Med
January 2025
The Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Objective: Despite the well-established increased risk of cardiovascular mortality in individuals with bipolar disorder (BD), prevention and treatment of cardiovascular risk factors and diseases have been largely overlooked in this population. This manuscript reviews the pathophysiological basis of the connection between BD and cardiovascular diseases, highlighting their shared mechanisms, reciprocal interactions, and relevant prevention and treatment strategies.
Methods: For this narrative review, a search was carried out on PubMed using the keywords bipolar disorder, cardiovascular diseases, and cardiovascular risk factors.
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders.
Cell
January 2025
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
A meta-genome-wide association study across eight psychiatric disorders has highlighted the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms underlying pleiotropic effects of the associated variants remain to be explored. We conducted a massively parallel reporter assay to decode the regulatory logic of variants with pleiotropic and disorder-specific effects.
View Article and Find Full Text PDFUnleashing creativity in people with Parkinson's disease: a pilot study of a co-designed creative arts therapy.
J Neurol
January 2025
Vienna Cognitive Science Hub, University of Vienna, Vienna, Austria.
Background: Conventional medical management, while essential, cannot address all multifaceted consequences of Parkinson's disease (PD). This pilot study explores the potential of a co-designed creative arts therapy on health-related quality of life, well-being, and pertinent non-motor symptoms.
Methods: We conducted an exploratory pilot study with a pre-post design using validated questionnaires.
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