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Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis.
J Adv Res
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao 999078, China; Guangdong-Hong Kong-Macau Join Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, University of Macau, Avenida da Universidade, Taipa, Macao 999078, China; Department of Pharmaceutical Sciences and Technology, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macao 999078, China. Electronic address:
Introduction: Non-alcoholic fatty liver disease (NAFLD) acts as the primary contributor to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and potentially hepatocellular carcinoma. The flowers of Chrysanthemum indicum, a traditional edible medicinal herb, have been widely used in China for more than 2000 years. However, the function of C.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Background: Obesity in midlife, body mass index (BMI) of 30 kg/m or higher, is recognized as a contributor to Alzheimer disease (AD) later in life. Adiposity in visceral tissues such as liver is associated with increased systemic inflammation and impaired cognition. In this study, we aimed to investigate the relationship between MRI-derived Positron Density Fat Fraction (PDFF) and brain histology and neuroinflammation using Diffusion Basis Spectrum Imaging (DBSI) in cognitively normal midlife individuals.
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Alzheimers Dement
December 2024
Herbert and Jackeline Krieger Klein Alzheimer's Research Center, Rutgers Biomedical and Health Sciences, Newark, NJ, USA.
Background: While body mass index (BMI) is widely used to gauge overall adiposity, its accuracy in older age has yielded inconsistent findings. Moreover, BMI does not account for variations in regional fat distribution, which may differ between sexes. This study aims to investigate whether regional adiposity plays a distinct role in impacting cognition and the volumes of AD-related brain regions in older adults with T2D enrolled in the Israel Diabetes and Cognitive Decline (IDCD) study.
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Alzheimers Dement
December 2024
Herbert and Jacqueline Krieger Klein Alzheimer's Research Center at Rutgers Brain Health Institute, New Brunswick, NJ, USA.
Background: High body mass index (BMI), which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. We examined associations of abdominal fat depots with cognition and brain volumes and whether sex modifies this association.
Method: 204 healthy middle-aged Alzheimer's-dementia (AD) offspring (mean age = 59.
Biomarkers.
Alzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Background: Obesity in midlife, defined as body mass index (BMI) of 30 kg/m or higher in those between 40-60 years, is related to higher Alzheimer's disease (AD) later in life. Non-alcoholic fatty liver disease, as a complication of obesity is associated with impaired cognitive function. We investigated the relationship between hepatic fat quantification by use of MRI-derived Positron Density Fat Fraction (PDFF) and brain cortical thickness in cognitively normal midlife individuals.
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