The arterial pressure was significantly higher in the calcium-deficient group of rats as compared with the normal rats: 150 +/- 7 and 116 +/- 2 mm Hg, resp. The first group of animals had a hypertensive factor in the blood. The hypertensive activity of the calcium-deficient animals was associated with no known pressor agents and was rather similar to Pang's hypertensive factor. The latter was also found in some patients with essential hypertension.
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