Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0035-9203(93)90055-u | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification and characterization of a carbohydrate recognition domain-like region in Gal/GalNAc lectin intermediate subunit.
Microbiol Spectr
November 2024
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Article Synopsis
- Unlabelled is a protozoan parasite that causes human diseases like amebic colitis, and its ability to adhere to host cells is crucial for its pathogenicity.
- The study identified a carbohydrate-recognition domain (CRD)-like region in the intermediate subunit (Igl) of a Gal-/GalNAc-inhibitable lectin, which contains two key CXXC motifs important for recognizing carbohydrates.
- This research enhances our understanding of the molecular mechanisms behind the parasite's adhesion and could help identify potential drug targets for treatment.
The octapeptide-repeat surface protein of Entamoeba nuttalli is a novel virulence factor that promotes adherence to host cells.
Biochem Biophys Res Commun
November 2024
Department of Parasitology, Tokai University School of Medicine, Isehara, Japan. Electronic address:
Entamoeba nuttalli is genetically the closest to Entamoeba histolytica, the causative agent of human amebiasis, and its natural host is Macaca species. A unique E. nuttalli specific surface protein (PTORS) containing 42 repeats of octapeptide was identified by comparative genomic analysis of Entamoeba species.
View Article and Find Full Text PDF: EhADH, an Alix Protein, Participates in Several Virulence Events through Its Different Domains.
Int J Mol Sci
July 2024
Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies of National Polytechnic Institute, Mexico City 07360, Mexico.
is the protozoan causative of human amoebiasis. The EhADH adhesin (687 aa) is a protein involved in tissue invasion, phagocytosis and host-cell lysis. EhADH adheres to the prey and follows its arrival to the multivesicular bodies.
View Article and Find Full Text PDFEffect of Stevioside () on Trophozoites.
Pathogens
April 2024
Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, Mexico City 07360, Mexico.
Human amoebiasis still represents a major health problem worldwide. Metronidazole has been used as the most common drug to treat the disease; however, it is also known that the drug causes undesirable side effects. This has led to the search for new pharmacological alternatives which include phytochemical compounds with antiamoebic effects.
View Article and Find Full Text PDFEntamoeba moshkovskii as a potential model organism for Gal/GalNAc lectin intermediate subunit exhibition and functional identification.
Drug Discov Ther
July 2024
Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
In humans, Entamoeba histolytica is the main pathogen causing various amoebiases, while E. moshkovskii falls between being a pathogen and non-pathogen. The two species have similar behavior patterns but differ significantly in pathogenicity, with previous studies and clinical data indicating that E.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!