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Novel Associations Between Major Histocompatibility Complex and Pediatric-onset Inflammatory Bowel Disease.
J Pediatr Gastroenterol Nutr
April 2016
*Children's Hospital †Transplantation Laboratory, Haartman Institute ‡Gastrointestinal Surgery §Immunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Hospital, Finland.
Purpose: Major histocompatibility complex (MHC) genes have been widely studied in adult inflammatory bowel disease (IBD), but data on MHC genes are scarce in pediatric IBD. This study focused on MHC association of genes with pediatric-onset IBD and its different phenotypes.
Methods: Blood samples of 103 patients with pediatric IBD (Crohn disease or ulcerative colitis) were collected at Children's Hospital, University of Helsinki, Finland.
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