Selenium supply of different populations might vary substantially according to the geographical location and eating habits. The authors pioneered in surveying the selenium supply of the Hungarian population in diverse parts of the country. The former was achieved by the study of multiple parameters characteristic of the human body's selenium status. Selenium levels were determined in sera of blood donors and in toe and fingernails of healthy village and city populations. Measurements in sera and in nails were performed by electrothermic atomic absorption spectroscopy and by flourimetric method, respectively. The average selenium concentration in sera was 0.70 micromol/liter, in fingernails was 0.61 mg/kg, in toenails it was 0.56 mg/kg. The average selenium concentration was significantly higher in the south-eastern and significantly lower in the south-western regions of the country compared to the northern countries. Similar regional differences could be observed in the average selenium content of both toe and fingernails. According to the findings, selenium deficiency could be verified even in the majority of persons with the highest selenium levels.
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Mol Cell Biochem
January 2025
Department of Urology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Selenium, an essential trace mineral for health, has seen a rise in clinical trials over the past nearly 5 decades. Our aim here is to provide a comprehensive and concise overview of selenium clinical trials from 1976 to 2023. Overall, the evolution of selenium clinical trials over 48 years has advanced through phases of emergence, prosperity, and either stability or transition.
View Article and Find Full Text PDFFood Chem
December 2024
Poznan University of Technology, Faculty of Chemical Technology, Berdychowo 4, 60-965 Poznań, Poland.. Electronic address:
The determination of iodine after the enrichment on solid sorbent ZrO in the combination with molecular absorption spectrometric (MAS) detection is presented. The detection limit and enrichment factor obtained were 0.009 μg mL and 9, respectively.
View Article and Find Full Text PDFEnviron Geochem Health
January 2025
Institute of Geophysical and Geochemical Exploration, Chinese Academy of Geological Sciences, No. 84, Jinguang Road, Langfang, 065000, China.
Selenium (Se) is an essential element for humans, playing a critical role in the functioning of the immune system. The global prevalence of dietary Se deficiency is a significant public health concern, largely attributed to the low levels of Se present in crops. The sufficient Se in plants and humans is determined by the presence of stable Se sources in the soil.
View Article and Find Full Text PDFAnal Chem
January 2025
Pukou Hospital of Chinese Medicine Affiliated to China Pharmaceutical University, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Inflammation, a central process in numerous diseases, plays a crucial role in hepatic disorders, arthritis, cardiac conditions, and neurodegenerative ailments. Given the lack of effective anti-inflammatory drugs, it is imperative to assess inflammation severity and explore novel therapeutics. Selenocysteine (Sec), a key mediator of selenium's biological function, is closely involved in anti-inflammatory responses.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Elevated iron in brain is a source of free radicals that causes oxidative stress which has been linked to neuropathologies and cognitive impairment among older adults. The aim of this study was to investigate the association of iron levels with transverse relaxation rate, R, and white matter hyperintensities (WMH), independent of the effects of other metals and age-related neuropathologies.
Method: Cerebral hemispheres from 437 older adults participating in the Rush Memory and Aging Project study (Table 1) were imaged ex-vivo using 3T MRI scanners.
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