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Digital Papillary Adenocarcinoma at the Site of 5 Years of Recurrent Paronychia: Case Report and Literature Review.
Case Rep Oncol Med
December 2024
Hand and Upper Extremity Surgery, Barrington Orthopedic Specialists, Schaumburg, Illinois, USA.
Article Synopsis
- Digital papillary adenocarcinoma (DPA) is a rare and often misdiagnosed malignant tumor, commonly mistaken for benign conditions, leading to delayed diagnosis and treatment.
- A 57-year-old man with recurrent finger infections was ultimately diagnosed with DPA after a surgical evaluation and biopsy revealed both infection and the tumor, necessitating surgical removal.
- Accurate diagnosis is vital due to the tumor's tendency for recurrence and metastasis, particularly to the lungs and lymph nodes, and current treatment primarily involves surgical excision with focus on achieving negative margins.
Proteomic profiling reveals the significance of lipid metabolism in small cell lung cancer recurrence and metastasis.
J Transl Med
December 2024
Department of Medical Oncology, Beijing Key Laboratory of Clinical Study On Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Background: Small cell lung cancer (SCLC) is a lethal and recalcitrant malignancy with early metastases. However, the molecular and cellular mechanisms underlying its aggressive characteristics remain relatively elusive.
Methods: In this study, we conducted a comprehensive proteomic analysis of 90 primary tumors, 15 patient-matched lymph node metastatic tumors, and 15 brain metastatic tumors derived from a cohort of 105 SCLC patients.
Fate of cultured populations when exposed to moxifloxacin.
Front Microbiol
November 2024
Winogradsky Institute of Microbiology, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.
Article Synopsis
- The study investigates how a small antibiotic-insensitive group of bacteria survives prolonged exposure to the antibiotic moxifloxacin, emphasizing the influence of factors like antibiotic concentration, growth stage, and potassium availability.
- Results show that bacterial responses vary significantly: mid-logarithmic cultures can regrow after initial killing by moxifloxacin, while stationary-phase cultures may experience gradual killing in potassium-deficient conditions.
- Electron microscopy reveals that bacteria in aggregates resist destruction longer than singular cells, and survivors exhibit diverse cell morphologies, suggesting varied responses to the same antibiotic dose based on the bacteria's physiological state.
Advances in laryngopharyngeal reflux: Etiology, diagnosis, and management.
Ann N Y Acad Sci
November 2024
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Article Synopsis
- * Diagnosis and treatment of LPR can be challenging due to its diverse subtypes, but advanced monitoring techniques and specific therapies are available to tailor management plans.
- * Ongoing research into LPR aims to improve understanding and develop new diagnostic and treatment strategies, including the use of pepsin inhibitors and comprehensive approaches to address laryngeal hypersensitivity.
Buccal fat pedicle flap with a delayed tarsoconjunctival flap for lower eyelid retraction: a new surgical methodology.
Orbit
October 2024
Department of Surgery, Trauma and Emergency Subspecialty Surgeons, Denver, Colorado, USA.
Purpose: The aim of this retrospective case review is to present a novel surgical technique used in the treatment of recalcitrant lower eyelid retraction.
Methods: This study was performed as a retrospective case review of 4 patients who have failed standard conservative surgical interventions for lower eyelid retraction repair. 3 patients developed lower eyelid retraction following surgical intervention for orbital trauma and 1 patient developed lower eyelid retraction in the setting of granulomatosis with polyangiitis.
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