Platform stabilometry is increasingly applied to monitor or re-educate standing balance in clinical rehabilitation. Consequently, insight is needed into the validity, reliability, and sensitivity of different force-platform parameters. This study focuses on the intrasubject variability as the major source of variance (unreliability) in the study of human motor skills. The intrasubject variability of several, commonly applied force-platform parameters was determined across ten repeated tests of quiet two-legged standing in healthy subjects to identify the most consistent and stable parameters in the quantification of postural control. The variability of the root mean square (RMS) amplitude, peak-to-peak amplitude, mean frequency, and RMS velocity of the fore-aft and lateral components of the center-of-pressure fluctuations was investigated under varying (visual and cognitive) task conditions. The results indicate that all selected parameters show considerable intrasubject variability irrespective of the task context. Nonetheless, both the RMS amplitude and RMS velocity in either direction of sway do not demonstrate a significant trend across repeated tests. Among the selected parameters, the RMS velocity in the fore-aft direction shows the greatest intrasubject consistency, as well as a high sensitivity to, for example, visual deprivation. These findings support the reliability and validity of this parameter in the clinical quantification of postural control.
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Background: Quantitative EEG measures can be used as biosignatures of disease conditions. As such, the effect of interventions/treatments can be studied by longitudinal analysis of changes in these measures. The consistency of these measures can be assessed by test-retest reliability scores such as intra-class correlation coefficient (ICC) that depends on intra- and inter-subject variability.
View Article and Find Full Text PDFPharmaceutics
December 2024
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
When companies are uncertain about the potential of a new formulation to be bioequivalent to a Reference product, it is common practice to carry out downsized pilot studies as a gatekeeping in vivo strategy to decide whether to move forward or not with a full-size pivotal study. However, due to the small study size, these studies are inarguably more sensitive to variability. To address and mitigate the uncertainty of the conclusions of pilot studies concerning the maximum observed concentration (C), the factor was proposed as an alternative approach to the average bioequivalence statistical methodology.
View Article and Find Full Text PDFClin Transl Sci
December 2024
Clinical Pharmacology, AbbVie Inc., North Chicago, Illinois, USA.
Recent reports suggest that plasma riboflavin may serve as a biomarker for BCRP inhibition in humans. However, the clinical data supporting this claim have been limited, with only two studies showing modest increases in riboflavin levels after administration of a BCRP inhibitor. We have recently demonstrated that co-administration of 375 mg once daily (q.
View Article and Find Full Text PDFJ Sports Sci
December 2024
Laboratoire Jeunesse, Activité Physique et Sportive, Santé (J-AP2S), Toulon Université, Toulon, France.
The aim of this study was to determine the minimum playing time in matches required to produce reliable acceleration - speed (AS) profiles from global navigation satellite system (GNSS) data. The playing time of 25 professional rugby union players was recorded using GNSS technology and segmented into four sections from 40, 80, 120 and 160 minutes of play. For each interval, the impact of integrating new match data on the AS profile was assessed, aiming to identify the saturation point where additional data did not induce significant changes in the profile outputs.
View Article and Find Full Text PDFBlood Press Monit
December 2024
Department of Cardiovascular Sciences, University of Leicester.
Objective: Remote patient monitoring (RPM) beat-to-beat blood pressure (BP) provides an opportunity to measure poststroke BP variability (BPV), which is associated with clinical stroke outcomes. BP sampling interval (SI) influences ambulatory BPV, but RPM BP SI optimisation research is limited. SI and RPM device capabilities require compromises, meaning SI impact requires investigation.
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