Ebola virus reproduction and morphological lesions were investigated in infected guinea pigs by electron microscopy. The liver was found to be the main target organ, whereas in other internal organs the pathological changes were insignificant. Ebola virus reproduction was demonstrated only in cells of the mononuclear phagocyte system.
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The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection.
Sci Adv
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Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Obeldesivir (ODV; GS-5245) is an orally administered ester prodrug of the parent nucleoside GS-441524 that has broad spectrum antiviral activity inhibiting viral RNA-dependent RNA polymerases. We recently showed that ODV completely protects cynomolgus macaques against lethal infection with Sudan virus when given 24 hours after parenteral exposure. Here, we report that once daily oral ODV treatment of cynomolgus and rhesus macaques for 10 days confers 80 and 100% protection, respectively, against lethal Ebola virus infection when treatment is initiated 24 hours after mucosal (conjunctival) exposure.
View Article and Find Full Text PDFAssociations of inflammatory markers with post-acute clinical findings among survivors of Ebola virus disease with and without viral RNA shedding in the semen in Liberia: a nested case-control study.
Lancet Microbe
March 2025
Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF), San Francisco, CA, USA; Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA; F.I. Proctor Foundation, University of California, San Francisco (UCSF), San Francisco, CA, USA; Institute for Global Health Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA. Electronic address:
Background: A high proportion of survivors of Ebola virus disease (EVD) have post-acute sequelae of EVD (PASE), but the relationship between inflammation and PASE pathogenesis is poorly understood. This study tests the hypothesis that inflammation is associated with PASE among survivors with and without viral RNA shedding in the semen.
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View Article and Find Full Text PDFStructural basis for Ebola virus nucleocapsid assembly and function regulated by VP24.
Nat Commun
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Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
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