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Comparative study of the oral hygiene status of users of mefakia (traditional tooth cleaning method) and modern toothbrushes among patients at the Holy Bethel Dental Clinic in Addis Ababa, Ethiopia.
BDJ Open
December 2024
School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Background: Mefakia is a well-known traditional chewing wood used in Ethiopia to cleanse the mouth. Although mefakia is used in parallel with modern toothbrushes to improve oral hygiene, there is a gap in the literature regarding its comparative performance in removing plaque and maintaining good oral hygiene.
Objective: This study aimed to evaluate and compare the oral hygiene status of patients using mefakia and modern toothbrushes at the Holy Bethel Dental Clinic in Addis Ababa, Ethiopia.
Cost-effectiveness analysis of proactive home visits compared with site-based community health worker care on antenatal care outcomes in Mali: a cluster-randomised trial.
BMJ Glob Health
December 2024
Muso, Bamako, Mali; San Francisco, USA.
Introduction: Despite recommendations from the WHO, antenatal care (ANC) coverage remains low in many low-income and middle-income countries (LMICs). Community health workers (CHWs) can play an important role in expanding ANC coverage through pregnancy identification, provision of health education, screening for complications, delivery of therapeutic care and referral to higher levels of care. However, despite the success of CHW programmes in various countries, WHO has called for additional research to develop evidence-based models that optimise CHW service delivery and that can be replicated across geographies.
View Article and Find Full Text PDFComparison of Population Pharmacokinetic Modeling and Machine Learning Approaches for Predicting Voriconazole Trough Concentrations in Critically Ill Patients.
Int J Antimicrob Agents
December 2024
Department of Pharmacy, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510163, China. Electronic address:
Despite the widespread use of voriconazole in antifungal treatment, its high pharmacokinetic and pharmacodynamic variability may lead to suboptimal efficacy, especially in intensive care unit (ICU) patients. Machine learning (ML), an artificial intelligence modeling approach, is increasingly being applied to personalized medicine. The effectiveness of ML models for predicting voriconazole blood concentrations in ICU patients, compared to traditional population pharmacokinetics (popPK) models, has been uncertain until now.
View Article and Find Full Text PDFConcomitant chronic lateral ankle instability affects postoperative functional outcomes in patients with osteochondral lesions of the talus, but does not affect cartilage repair after restoration of ankle stability.
Arthroscopy
December 2024
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:
Purpose: To investigate the effect of concomitant chronic lateral ankle instability (CLAI) on postoperative clinical outcomes in patients with osteochondral lesions of the talus (OLTs).
Methods: Patients who underwent surgery for OLTs between January 2018 and May 2022 were retrospectively evaluated. OLT procedures involved debridement, microfracture, or bone grafting, while concomitant CLAI underwent lateral ligament repair or reconstruction.
Microelectricity enhances aerobic granular sludge granulation and sulfamethazine degradation: Performance, mechanism, antibiotic resistance genes and microbial community.
J Environ Manage
December 2024
College of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, PR China.
With the widespread use of typical antibiotics such as sulfamethazine (SMT), it leads to their accumulation in the environment, increasing the risk of the spread of antibiotic resistance genes (ARGs). Aerobic granular sludge (AGS) has shown great potential in treating antibiotic wastewater. However, the long cultivation period of AGS, the easy disintegration of particles and the poor stability of degradation efficiency for highly concentrated antibiotic wastewater are still urgent problems that need to be solved, and it is important to explore the migration and changes of ARGs and microbial diversity in AGS systems.
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