Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NORs) have been studied in paraffin sections of 76 non-Hodgkin's lymphomas, five normal lymph nodes, and five <
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LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells.
Genes Dev
December 2024
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3H7, Canada;
The nucleolus is a major subnuclear compartment where ribosomal DNA (rDNA) is transcribed and ribosomes are assembled. In addition, recent studies have shown that the nucleolus is a dynamic organizer of chromatin architecture that modulates developmental gene expression. rDNA gene units are assembled into arrays located in the p-arms of five human acrocentric chromosomes.
View Article and Find Full Text PDFThe first record of a European black fly, Simulium ichnusae Rivosecchi & Contini, is documented for Africa, where it was found at elevations above 1000 m in the Djurdjura Mountains of Algeria. Considered an endemic species of Sardinia for 60 years, S. ichnusae must now be regarded as pseudoendemic.
View Article and Find Full Text PDFEstablishment and characterization of the Cuvier's beaked whale (Ziphius cavirostris) myogenic cell line.
Res Vet Sci
January 2025
Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, PD, Italy.
Article Synopsis
- This study presents a novel in vitro muscle-derived cell line from a stranded male Cuvier's Beaked whale, facilitating research on its myogenic cells.
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Anti-NOR90 antibodies and their clinical significance: a multicenter experience in southern Spain.
Rev Clin Esp (Barc)
January 2025
Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario Clínico San Cecilio, Granada, Spain.
Introduction: Anti-NOR90 antibodies were initially described in patients with autoimmune diseases based on staining of a nucleolar region known as the nucleolar organizer region (NOR). This study aims to explore the clinical aspects of anti-NOR90 antibodies in patients with systemic autoimmune diseases.
Methods: Observational study of patients with positive anti-NOR90 antibodies using the EUROLINE Systemic Sclerosis profile (IgG) kit (Euroimmun, Germany).
The value and significance of nucleolar organizer region proteins as markers of malignancy in breast cancer patients.
Saudi Med J
October 2024
From the Department of Clinical Laboratory Sciences (Salih, Dahlawi), College of Applied Medical Sciences, Taif University, Taif, from the Department of Medical Laboratory (Abdulgafor), King Faisal Special Hospital Research Center, Al-Madinah Al-Munawarah, and from the Department of Laboratory Medicine (Khalifa), Faculty of Applied Medical Science, University of Al Baha, Al Baha, Kingdom of Saudi Arabia.
Objectives: To assess argyrophilic nucleolar organizer regions (AgNORs) in 60 patients with primary breast carcinoma and evaluated their association with clinical prognostic parameters of breast cancer.
Methods: Argyrophilic nucleolar organizer regions were stained in paraffin sections of the tissues using Ploton's silver method. For each sample, the number of AgNORs within the nuclei of 100 tumor cells was counted.
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