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Inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase diminishes the survival and size of chondrocytes during orofacial morphogenesis in zebrafish.
Orthod Craniofac Res
August 2023
Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Objectives: The 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) is the enzyme controlling the rate-limiting step in the synthesis of cholesterol, sterols, and isoprenoids in the mevalonate biosynthetic pathway. Impaired function of HMGCR in zebrafish produces craniofacial malformations and orofacial cleft, mainly affecting the post-migratory neural crest cells with little earlier effect. Here we investigate morphogenetic and cellular mechanisms underlying the generation of these malformations.
View Article and Find Full Text PDFNasal sinuses cholesteatoma: case series and review of the English literature.
Eur Arch Otorhinolaryngol
February 2023
Department of Otorhinolaryngology, Faculty of Medicine, Ain Shams University, Cairo, 11331, Egypt.
Background: Nasal sinus cholesteatomas are uncommon slow-growing lesions that are frequently misdiagnosed preoperatively. They can develop due to embryologic remnants or iatrogenic factors (surgical trauma or nasal sinus trauma). In addition, they can cause bone destruction resulting in intracranial or intraorbital complications as well as malignant change if neglected.
View Article and Find Full Text PDFModified Lothrop (Draf III) procedure for the treatment of a recurrent orbitofrontal cholesterol granuloma: A case report.
SAGE Open Med Case Rep
February 2020
Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Article Synopsis
- - A 64-year-old man with a history of trauma and previous sinus surgery experienced recurrent orbitofrontal cholesterol granuloma, presenting symptoms like nasal congestion, loss of smell, and double vision.
- - Initial CT scans indicated a mass linked to chronic sinusitis, leading to the diagnosis of cholesterol granuloma after endoscopic surgery removed the cyst.
- - The lesion recurred after two months, requiring a Modified Lothrop (Draf III) procedure, which successfully prevented relapse over a five-year period, highlighting its effectiveness as a treatment option.
Cholesterol granuloma of ethmoid sinuses: Report of two cases.
Acta Otorrinolaringol Esp (Engl Ed)
June 2018
Maryland Nose & Sinus Center at MedStar Union Memorial Hospital, Baltimore, MD, United States.
Cholesterol granuloma (CG) is common in the mastoid air cells, less common in the skull base and orbit, and uncommon in the paranasal sinuses. The most commonly affected sinus is the maxillary sinus, and it is very rare in the ethmoid and sphenoid sinus. CG is thought to be due to impair the venous and lymphatic drainage from the sinus cavity.
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