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HIV and spinal cord disease.
Handb Clin Neurol
September 2018
Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address:
The epidemiology of spinal cord disease in human immunodeficiency virus (HIV) infection is largely unknown due to a paucity of data since combination antiretroviral therapy (cART). HIV mediates spinal cord injury indirectly, by immune modulation, degeneration, or associated infections and neoplasms. The pathologies vary and range from cytotoxic necrosis to demyelination and vasculitis.
View Article and Find Full Text PDFCentral nervous system infections in HIV-infected patients hospitalized at King Chulalongkorn Memorial Hospital.
J Med Assoc Thai
May 2011
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Background: Central nervous system (CNS) infections are among one of the most common complications in HIV-infected patients. The present study aimed to determine the etiologies, clinical features, treatment, and outcomes of all CNS infections in HIV-infected patients.
Material And Method: A retrospective study was carried out in all adult HIV-infected patients with CNS infection who were hospitalized at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, from January 1, 2007 to December 31, 2008.
Neuropathology of myelitis, myelopathy, and spinal infections in AIDS.
Neuroimaging Clin N Am
August 1997
Clinical Department of Neuropathology and Neurochemistry, University of Vienna, Austria.
In AIDS, pathology in the spinal contents usually follows that in the brain but is less frequent. Opportunistic infections are found in an average of 9.5% of spinal AIDS autopsies but in 54% of autopsies of the whole CNS.
View Article and Find Full Text PDFThe pathology of cytomegalovirus (CMV) encephalitis was studied at autopsy in thirty patients with acquired immunodeficiency syndrome. Lesions could be segregated into five major categories: microglial nodules, isolated inclusion-bearing cells, focal parenchymal necrosis, necrotizing ventriculo-encephalitis, and necrotizing radiculo-myelitis. Microglial nodules and CMV inclusions were present in all brains.
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