[Investigations concerning the influence of cefuroxime and amikacin on dynamics of selected parameters of nonspecific cellular immunity in experimental animals].

Rabbits divided into two groups were injected intramuscularly antibiotics amikacin or cefuroxime in doses corresponding to mean therapeutic doses for seven days. Blood samples for determination of values of phagocytosis reaction (percentage of phagocytizing neutrophils, phagocyte index) and NBT test were taken before application of antibiotics and on 7, 14, 28 and 42 day of study. After application of cefuroxime significant decrease of NBT value was observed at the 14th day, whereas the percentage of phagocytizing neutrophils was changing at 7 and 14 day. Phagocytic index did not change. After application of amikacin, percentage of phagocytizing granulocytes was significantly decreased (7, 14 and 28 day). Phagocytic index did not change. NBT test value was lowered at 14 day, but it increased at the 42 day.