Diethylaminoethyl-dextran exhibited a significant effect on the primary immune response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine (IVEE). Antibody formed to IVEE and adjuvant followed a classic immunoglobulin M-immunoglobulin G pattern; however, as compared with vaccine alone, use of this adjuvant with IVEE reduced the time required for onset of immunoglobulin G synthesis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420800PMC
http://dx.doi.org/10.1128/iai.13.6.1559-1562.1976DOI Listing

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