Neurologic paraneoplastic syndromes are medical and nursing challenges. Although neurologic paraneoplastic syndromes are relatively rare in the total cancer population, they may be more commonly seen in the acute neurologic setting. O'Neill et al estimate that 60% of persons with Eaton-Lambert syndrome and 50% of persons with subacute cerebellar degeneration have an underlying cancer. The slow and subtle development of neurologic paraneoplastic disorders underscores the need for careful evaluation of persons with neurologic deficits. Once the diagnosis is made, nursing care must be based on the problems associated with paraneoplastic manifestations of the disease, as well as effects of the cancer and its treatment.
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http://dx.doi.org/10.1097/01376517-199308000-00006 | DOI Listing |
Neurol Neuroimmunol Neuroinflamm
March 2025
MeLis Institute, SynatAc Team, Inserm U1314/ UMR CNRS5284, France.
Background And Objectives: Breast cancers (BCs) of patients with paraneoplastic neurologic syndromes and anti-Yo antibodies (Yo-PNS) overexpress human epidermal growth factor receptor 2 (HER2) and display genetic alterations and overexpression of the Yo-onconeural antigens. They are infiltrated by an unusual proportion of B cells. We investigated whether these features were also observed in patients with PNS and anti-Ri antibodies (Ri-PNS).
View Article and Find Full Text PDFJ Int Med Res
January 2025
Department of Gastroenterology & Hepatology, Dazhou Integrated TCM and Western Medicine Hospital: Dazhou Second People's Hospital, Dazhou, Sichuan Province, China.
Paraneoplastic chronic intestinal pseudo-obstruction (CIPO) is a rare manifestation associated with small cell lung carcinoma and other malignancies. In this report, we present a challenging case involving a 60-year-old man with small cell lung carcinoma who developed symptoms of intestinal pseudo-obstruction, including abdominal distention, pain, and obstipation. Despite receiving extensive treatment with intravenous gamma globulin and glucocorticoids, the patient's symptoms did not improve, ultimately resulting in irreversible nervous system damage.
View Article and Find Full Text PDFNarra J
December 2024
Department of Epidemiology, Biostatistics, Population Studies and Health Promotion, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
Patients with generalized myasthenia gravis (MG) often show restrictive spirometry results. Although regular exercise and physical fitness are linked to better respiratory function, there is limited research assessing the effects of aerobic exercise on lung function in MG patients. The aim of this study was to analyze the effect of low-intensity aerobic exercise using a cycle ergometer on lung function parameters in MG patients.
View Article and Find Full Text PDFMov Disord Clin Pract
January 2025
The Edmond J. Safra Program in Parkinson's Disease, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
BMJ Case Rep
January 2025
Department of Dermatology, Venereology and Leprosy, Nital Skin Clinic, Karad, Maharashtra, India.
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