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Characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies in adults in the UK General Practice: a population-based cohort study.
J Infect
January 2025
Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Research Department of Practice and Policy, School of Pharmacy, University College London, London, United Kingdom; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Hong Kong.
Objective: To assess the characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies labels in general practice in the UK.
Design: Population-based cohort study.
Setting: Primary care in the UK, 2000-2018.
Performance of clinical decision aids (CDA) for the care of young febrile infants: a multicentre prospective cohort study conducted in the UK and Ireland.
EClinicalMedicine
December 2024
Wellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, UK.
Background: Between 1% and 4% of febrile infants, aged from birth to 90 days of age, presenting to hospital will be diagnosed with an invasive bacterial infection (IBI). Traditional teaching has advocated a treat all approach but more recently a number of clinical decision aids (CDA) have been developed to classify febrile infants into lower and higher risk cohorts, with lower risk infants suitable for management without immediate parenteral antibiotics and lumbar puncture. The aim of this study was to apply these CDA to a UK and Irish cohort.
View Article and Find Full Text PDFFactors influencing implementation and adoption of direct oral penicillin challenge for allergy delabelling: a qualitative evaluation.
BMJ Open Qual
September 2024
Department of Allergy and Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Background: Over 95% of penicillin allergy labels are inaccurate and may be addressed in low-risk patients using direct oral penicillin challenge (DPC). This study explored the behaviour, attitudes and acceptability of patients, healthcare professionals (HCPs) and managers of using DPC in low-risk patients.
Methods: Mixed-method, investigation involving patient interviews and staff focus groups at three NHS acute hospitals.
Prescription Patterns of Inducers and Inhibitors of Cytochrome P450 and Their Potential Drug Interactions in the Real World: A Cross-Sectional Study.
Drugs Real World Outcomes
December 2024
Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A, Calle 105 No. 14-140, 660003, Pereira, Risaralda, Colombia.
Introduction: Both the induction and inhibition of cytochrome P450 are associated with multiple pharmacological interactions, which can lead to loss of efficacy or increase the risk of adverse drug reactions.
Objective: The aim was to determine the prescription patterns of cytochrome P450-inducing and -inhibiting drugs and their contraindicated and major pharmacological interactions in a group of patients from Colombia.
Methods: This cross-sectional observational study included patients who received drugs that induce or inhibit metabolism and examined their contraindicated and major pharmacological interactions.
Characterizing the evolving SARS-CoV-2 seroprevalence in urban and rural Malawi between February 2021 and April 2022: A population-based cohort study.
Int J Infect Dis
December 2023
Malawi Epidemiology and Intervention Research Unit, Malawi; London School of Hygiene and Tropical Medicine, London, United Kingdom; School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Article Synopsis
- The study explored changes in SARS-CoV-2 seroprevalence in Malawi from February 2021 to April 2022, looking at factors like health, age, and location.
- Four serosurveys were conducted in urban and rural areas to measure antibody levels, involving over 2,000 participants, with significant increases in seroprevalence noted.
- Results showed high seroprevalence with low health impacts, suggesting a need to adjust national vaccination strategies to focus on at-risk populations rather than universal vaccination.
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