AI Article Synopsis
- A new method calculates the glomerular filtration rate (GFR) using only plasma creatinine concentration and without urine collection.
- This method determines the urinary excretion rate of creatinine from a measured GFR and plasma creatinine concentration using a specific equation.
- The reliability of this approach was validated by strong agreement between calculated and measured GFR in various patient groups, and a nomogram for practical use will be available in the same journal issue.
Article Abstract
A method for calculating glomerular filtration rate (GFR) in the individual patient from plasma creatinine concentration only is presented. By this method the urinary excretion rate of creatinine (u) in the individual patient is determined indirectly from a simultaneous determination of GFR (measured without urine collection from the total [51Cr]EDTA plasma clearance) and plasma concentration of creatinine (p) according to the equation u =p(0.968GFR + 4.11), in which the expression in parentheses corresponds to the regression of endogenous creatinine clearance on GFR as determined in 67 patients, covering a wide range of renal function. Hereafter (as long as u is constant), GFR in the individual patient is calculated solely from any new determination of p according to the equation GFR = (u/p-4.11)/0.968. The reliability of the method was confirmed by the finding of a close correspondence between the values of calculated GFR and measured GFR in 6 patients with rapid changes in renal function and in 14 patients investigated twice with a time interval of 5-18 months. The practical application of the method by a nomogram is presented elsewhere in this issue of the journal.
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| http://dx.doi.org/10.3109/00365517609055275 | DOI Listing |
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