Alterations in elemental composition of the normal lens have been reported to accompany galactose cataract development in rats. In this report we present the changes in regional distribution of Na, K, Cl, P, S and Ca during the reversal of galactose-induced cataracts. Elemental X-ray maps of lenses from young female Sprague Dawley rats fed 50% galactose for 20 days were examined at 0, 20, 40 and 90 days following the transfer of galactose fed rats to Purina Rat Chow diet. Reinstatement of normal elemental distribution accompanied the progression of lens transparency. By 90 days on the rat chow diet, K had increased and Na, Cl and Ca had decreased so that a near normal lenticular distribution of these elements was established. The reinstatement of elemental distribution during cataract reversal followed a pattern similar to that observed for alterations during cataract development, initiating near the equatorial surface and expanding centrally. The correlation between the alterations in the distribution of the elements studied and our previously reported morphological investigation of lenses during galactose cataract reversal is discussed in this report.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/02713689309001847 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of genes contributing to attenuation of rat model of galactose-induced cataract by pyruvate.
Genes Cells
October 2024
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan.
Article Synopsis
- - Cataracts, specifically diabetic cataracts, cause vision problems due to lens opacity and can develop quickly in younger individuals; effective treatments have been sought.
- - Research indicates that pyruvate can reduce oxidative stress and slow down the progression of lens opacity in a rat model when lenses are cultured in a high-galactose medium.
- - Microarray and RT-qPCR analyses identified 34 candidate genes involved in the therapeutic effects of pyruvate, with a focus on metallothionein-related and epithelial-mesenchymal transition-related factors that may play significant roles in combating cataract formation.
Health and well-being of maturing adults with classic galactosemia.
J Inherit Metab Dis
January 2025
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
Article Synopsis
- A study analyzed long-term health outcomes in 92 adults (ages 30-78) with classic galactosemia (CG) and 38 unaffected siblings (ages 30-79) using anonymous surveys covering various health domains.
- Results showed that long-term complications in areas such as cognition, motor function, and psychosocial well-being persisted similarly to reports from younger groups, suggesting these issues do not worsen with age for most CG patients.
- The study explored connections between health outcomes and factors like early diet restrictions and age, finding some links to cataracts and bone health, but no significant trends were observed overall.
Phenotypic and genetic spectra of galactose mutarotase deficiency: A nationwide survey conducted in Japan.
Genet Med
August 2024
Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
Purpose: Galactose mutarotase (GALM) deficiency was first reported in 2019 as the fourth type of galactosemia. This study aimed to investigate the clinical and genotypic spectra of GALM deficiency.
Methods: This was a questionnaire-based retrospective survey conducted in Japan between February 2022 and March 2023.
EXAMINATION OF GALACTOMANNAN LEVELS IN INTRAOCULAR FLUID TO ASSIST THE DIAGNOSIS OF ASPERGILLUS ENDOPHTHALMITIS.
Retina
August 2024
The Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Purpose: To evaluate the utility of galactomannan testing of intraocular fluid in the diagnosis of Aspergillus endophthalmitis (AE).
Methods: This retrospective study enrolled three groups of patients, including those with 17 eyes with AE; 20 eyes with intraocular infection of bacteria, viruses, or other fungi; and 19 eyes with cataract. Intraocular fluid from all these patients was collected for galactomannan testing.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!