The effects of neonatal capsaicin treatment (50 mg/kg, SC, at day 2 of postnatal life) on C-fiber excitability and dorsal horn C-input processing were studied through recording of a C-fiber-evoked spinal flexor reflex in 55-60-day-old rats, anesthetized with urethane (1.1 g/kg, IP) and spinalized at Th9-10. Neonatal capsaicin resulted in decreased C-fiber excitability, as revealed by increased chronaxie values determined in a strength-duration paradigm. Besides, capsaicin-treated rats exhibited a reduced potentiation of the C-reflex discharge in response to repetitive stimulation. The results indicate that capsaicin given to rats early in life leads to both functional disturbances of surviving C-fibers and altered temporal synaptic processing of the C-input in the spinal cord.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0361-9230(93)90174-a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Advillin Knockout on Diabetic Neuropathy Induced by Multiple Low Doses of Streptozotocin.
J Physiol Investig
December 2024
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Advillin is an actin-binding protein involved in regulating the organization of actin filaments and the dynamics of axonal growth cones. In mice, advillin is exclusively expressed in somatosensory neurons, ubiquitously expressed in all neuron subtypes during neonatal ages and particularly enriched in isolectin B4-positive (IB4+) non-peptidergic neurons in adulthood. We previously showed that advillin plays a key role in axon regeneration of somatosensory neurons during peripheral neuropathy.
View Article and Find Full Text PDFThe effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.
Am J Physiol Gastrointest Liver Physiol
July 2024
Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio, United States.
The neural connectivity among the oral cavity, pharynx, and esophagus is a critical component of infant feeding physiology. Central integration of oral and pharyngeal afferents alters motor outputs to structures that power swallowing, but the potential effects of esophageal afferents on preesophageal feeding physiology are unclear. These effects may explain the prevalence of oropharyngeal dysphagia in infants suffering from gastroesophageal reflux (GER), though the mechanism underlying this relationship remains unknown.
View Article and Find Full Text PDFNHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
Am J Physiol Gastrointest Liver Physiol
May 2024
Ardelyx, Inc., Waltham, Massachusetts, United States.
Article Synopsis
- The pathogenesis of irritable bowel syndrome (IBS) involves factors like increased intestinal permeability and visceral hypersensitivity, leading to symptoms like abdominal pain and severity of the condition.
- Tenapanor, an FDA-approved treatment for IBS with constipation, has shown to improve bowel motility and alleviate IBS-related pain, though the precise mechanism of action is not fully understood.
- Research indicates that tenapanor reduces pain by improving intestinal barrier function and decreasing permeability, which in turn decreases pain signaling in the gut.
Pasteurized improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice.
Gut Microbes
January 2024
NeuroDol, UMR 1107 INSERM, University of Clermont Auvergne, Clermont-Ferrand, France.
Gut - brain communications disorders in irritable bowel syndrome (IBS) are associated with intestinal microbiota composition, increased gut permeability, and psychosocial disturbances. Symptoms of IBS are difficult to medicate, and hence much research is being made into alternative approaches. This study assesses the potential of a treatment with pasteurized Akkermansia muciniphila for alleviating IBS-like symptoms in two mouse models of IBS with different etiologies.
View Article and Find Full Text PDFThe triple function of the capsaicin-sensitive sensory neurons: In memoriam János Szolcsányi.
Temperature (Austin)
November 2022
Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti str. 12, H-7624, Pécs, Hungary.
This paper is dedicated to the memory of János Szolcsányi (1938-2018), an outstanding Hungarian scientist. Among analgesics that act on pain receptors, he identified capsaicin as a selective lead molecule. He studied the application of capsaicin and revealed several physiological (pain, thermoregulation) and pathophysiological (inflammation, gastric ulcer) mechanisms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!