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Ondansetron usage in HIV positive patients: a pilot study on the control of nausea and vomiting in patients on high dose co-trimoxazole for Pneumocystis carinii pneumonia. | LitMetric

AI Article Synopsis

  • The study assessed ondansetron's safety and efficacy in managing nausea and vomiting caused by co-trimoxazole in AIDS patients with Pneumocystis carinii pneumonia.
  • Out of 16 patients, 69% experienced good control of vomiting on their worst day, while 50% managed to control it throughout treatment; 47% achieved mild or no nausea.
  • The findings suggest that ondansetron could be a viable alternative if standard anti-emetics fall short or cause unacceptable side effects, with one serious adverse event reported but not linked to the drug.

Article Abstract

This was an open, single centre study, to evaluate the safety and efficacy of ondansetron in the treatment of co-trimoxazole associated nausea and vomiting in AIDS patients. Sixteen patients presenting with their first episode of HIV-associated Pneumocystis carinii pneumonia (PCP) on high dose co-trimoxazole were given ondansetron 8 mg orally, every 8 h. Measurements were made from data recorded by each patient on diary cards. In this study 11 out of 16 (69%) patients on ondansetron experienced good control of emesis (2 or less emetic episodes) on their 'worst day' of therapy and 8 out of 16 (50%) of patients demonstrated good control of emesis throughout their treatment with co-trimoxazole. Good control of nausea (mild or none) was achieved in 7 out of 16 (47%) patients. A total of 7 patients were able to complete the full course of co-trimoxazole whilst on ondansetron. One serious adverse event (Stevens-Johnson syndrome) was reported and felt to be unrelated to ondansetron. If conventional anti-emetics fail to achieve control of symptoms or have unacceptable side effects, ondansetron may represent a possible alternative.

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Source
http://dx.doi.org/10.1177/095646249300400508DOI Listing

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