The injection of free non-reactive hapten, before immunization with the same hapten conjugated to one carrier protein, induces specific unresponsiveness to the hapten in Rats. Two haptens have been assayed: dinitrophenyl-Lysine and Arsonate-Tyrosine. In both cases, the Rats responded normally to the carrier but did not respond to the hapten. These results can be explained by assuming that the hapten blocks the specific receptors of the immunocompetent cells.
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