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Laminar Fluid Ejection for Olfactory Drug Delivery: A Proof of Concept Study.
IEEE J Transl Eng Health Med
December 2024
Rocket Science Health Victoria BC V8V 2Y1 Canada.
Focal intranasal drug delivery to the olfactory cleft is a promising avenue for pharmaceuticals targeting the brain. However, traditional nasal sprays often fail to deliver enough medication to this specific area. We present a laminar fluid ejection (LFE) method for precise delivery of medications to the olfactory cleft.
View Article and Find Full Text PDF[Effect of electroacupuncture on blood-brain barrier and central inflammatory response in obese rats].
Zhen Ci Yan Jiu
December 2024
College of Acupuncture-moxibustion and Orthopedics-traumatology, Hubei University of Chinese Medicine, Wuhan 430060, China.
Objectives: To observe the effect of electroacupuncture (EA) on central nervous inflammatory response in obese rats, so as to explore its mechanisms underlying improvement of obesity.
Methods: Male SD rats were randomly allocated to normal control, model, EA and sham-EA groups (=15/group). Rats of the normal group were fed with normal diet, and the obesity model was established by feeding the rats with high-fat diet for 8 weeks.
Does primary posterior tracheopexy prevent collapse of the trachea in newborns with oesophageal atresia and tracheomalacia? A study protocol for an international, multicentre randomised controlled trial (PORTRAIT trial).
BMJ Open
December 2024
Congenital Oesophageal and Airway Team Utrecht, Departments of Paediatric Surgery and Otorhinolaryngology and Head and Neck Surgery, Wilhelmina Children's Hospital University Medical Center, Utrecht, The Netherlands.
Introduction: Tracheomalacia (TM) often occurs in children with oesophageal atresia (OA), leading to recurrent respiratory symptoms and in severe cases to blue spells or ultimately respiratory arrest. In some patients, a secondary posterior tracheopexy may then be indicated. This secondary surgery, as well as respiratory morbidity, may be prevented by performing a primary posterior tracheopexy (PPT) concurrent with primary OA correction.
View Article and Find Full Text PDFAn Uncommon Encounter: Metastatic Olfactory Neuroblastoma in an Adult Male.
Cureus
November 2024
Department of Medical Oncology, 251 Air Force General Hospital, Athens, GRC.
Olfactory neuroblastoma is an extremely rare malignancy of the sinonasal tract. It is a neuroectodermal tumor, originating from the olfactory epithelium of the nasal and sinus cavities. Due to its rarity, no standard of care treatments have been established to date.
View Article and Find Full Text PDFPathologically altered articular cartilage attracts intense chondrocyte invasion into the extracellular matrix: in vitro pilot study.
Knee Surg Relat Res
December 2024
National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva st. 4, 249036, Obninsk, Russia.
Background: Due to non-vascularized and aneural structure, articular cartilage has limited self-repairing capacity. The aim of this study was to investigate the revitalization of inflammatory injured articular cartilage matrices by human nasal chondrocytes (hNC).
Materials And Methods: Cartilage matrix was prepared by devitalization of articular cartilage samples obtained intraoperatively from an adult patient undergoing knee joint replacement.
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