Twelve patients, three male and nine female, suffering from hypertrophic obstructive cardiomyopathy were operated during the period 1976 to 1991. Operative methods were myotomy-myectomy (Morrow-procedure), mitral valve implantation or both. During the perioperative period two patients developed conduction disturbances requiring pacemaker implantation, five patients had left bundle branch block, and one died. The NYHA class was significantly reduced postoperatively (p = 0.0002). Five of eleven patients surviving the perioperative period died postoperatively after a mean follow-up of 6.3 years. It is the authors' opinion, that operation should be considered in patients suffering from hypertrophic obstructive cardiomyopathy, who have a left ventricle outflow gradient of 50 mmHg or more, and who despite medical treatment have symptoms placing them in NYHA class III-IV.
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Zhonghua Nei Ke Za Zhi
February 2025
Department of Cardiology, Peking University First Hospital, Beijing100034, China Institute of Cardiovascular Disease, Peking University First Hospital, Beijing100034, China Echocardiography Core Lab, Institute of Cardiovascular Disease, Peking University First Hospital, Beijing100034, China.
Animals (Basel)
January 2025
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.
Background: Purring in cats can interfere with cardiac auscultation. If the produced noise is loud enough, purring makes it impossible to perform a meaningful auscultation as it is much louder than heart sounds and murmurs. Our study introduced and tested a new, simple, fear-free, cat-friendly method to stop purring during auscultation.
View Article and Find Full Text PDFAm J Cardiol
January 2025
Department of Cardiovascular Medicine, Baystate Medical Center and Division of Cardiovascular Medicine, University of Massachusetts-Baystate, Springfield, Massachusetts, USA. Electronic address: https://twitter.com/AGoldsweig.
Introduction: Obstructive hypertrophic cardiomyopathy (oHCM) is a genetic disorder characterized by myocardial hypertrophy, which can obstruct left ventricular outflow. Cardiac myosin inhibitors (CMIs) have emerged as a novel therapeutic agent targeting cardiac muscle hypercontractility.
Objective: To compare the efficacy and safety of CMIs mavacamten and aficamten vs.
J Cardiothorac Surg
January 2025
Department of Cardiothoracic Surgery, Mayo Clinic, Jacksonville, FL, USA.
Mitral and aortic annular calcification is an age-related degenerative process that can result in severe mitral and/or aortic stenosis and/or regurgitation. Annular calcification not only increases the surgical complexity but also increases the risk of complications. In this case report, we present the innovative use of the Sonopet ultrasonic surgical aspirator for aortic and mitral annular decalcification in a patient with hypertrophic obstructive cardiomyopathy, mild aortic stenosis and moderate mitral regurgitation in the presence of mitral annular calcification (MAC) and aorto-mitral curtain calcification.
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January 2025
Yonsei University College of Medicine, Seoul, The Republic of Korea
Background: High-intensity physical activity has traditionally been discouraged in patients with hypertrophic cardiomyopathy due to concerns about triggering sudden cardiac death. However, current guidelines adopt a more liberal stance, and evidence on risk factors for exercise-related sudden cardiac death remains limited. This study investigated the clinical, morphological and genetic factors associated with high-intensity physical activity-related sudden cardiac death in hypertrophic cardiomyopathy.
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