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NIR photo-responsive injectable chitosan/hyaluronic acid hydrogels with controlled NO release for the treatment of MRSA infections.
Int J Biol Macromol
January 2025
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530000, China. Electronic address:
Due to resistance to common antibiotics, methicillin-resistant Staphylococcus aureus (MRSA) infections pose a significant threat to human health. In this study, we developed an injectable, adhesive, and biocompatible hydrogel with multiple functions. Specifically, carboxymethyl chitosan (CMCS) crosslinked with hyaluronic acid (HA) forms the primary framework of the hydrogel.
View Article and Find Full Text PDFBiomimetic Natural Biomaterial Nanocomposite Scaffolds: A Rising Prospect for Bone Replacement.
Int J Mol Sci
December 2024
Biotechnology Center, The Silesian University of Technology, 44-100 Gliwice, Poland.
Biomimetic natural biomaterial (BNBM) nanocomposite scaffolds for bone replacement can reduce the rate of implant failure and the associated risks of post-surgical complications for patients. Traditional bone implants, like allografts, and autografts, have limitations, such as donor site morbidity and potential patient inflammation. Over two million bone transplant procedures are performed yearly, and success varies depending on the material used.
View Article and Find Full Text PDFPatient Experience and Wound Healing Outcomes Using Different Palatal Protection Methods After Free Gingival Grafts: A Systematic Review.
J Funct Biomater
November 2024
Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 71-111 Szczecin, Poland.
(1) Background: A free gingival graft (FGG) is a common technique used to reconstruct or enhance the area of keratinized mucosa, while a connective tissue graft (CTG) is utilized to boost soft tissue thickness, thereby promoting stability in interproximal marginal bone levels. Most reported complications following FGG procedure are associated with the donor site. In addition to a painful, open wound in the palate, the most frequent complications linked to FGG harvesting include excessive bleeding, postoperative bone exposure, and recurrent herpes lesions.
View Article and Find Full Text PDFSilybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects.
J Cosmet Dermatol
January 2025
Science and Technology, Givaudan France SAS, Pomacle, France.
Background: Vitamin A, or retinol, is one of the most effective antiaging molecules, but it presents issues with photo-sensitivity and irritation. Alternatives are emerging, but have so far been less effective.
Objective: Here, we present a Silibum marianum extract (SME) as a retinol-like ingredient providing both safety and efficacy.
Exploratory study of extracellular matrix biomarkers for non-invasive liver fibrosis staging: A machine learning approach with XGBoost and explainable AI.
Clin Biochem
January 2025
Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
Background: Novel circulating markers for the non-invasive staging of chronic liver disease (CLD) are in high demand. Although underutilized, extracellular matrix (ECM) components offer significant diagnostic potential. This study evaluates ECM-related markers in hepatitis C virus (HCV)-positive patients across varying fibrosis stages.
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